Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2100202..2100719 Replicon chromosome
Accession NZ_CP081257
Organism Phaeobacter inhibens strain M636

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag K4L01_RS10085 Protein ID WP_260098718.1
Coordinates 2100202..2100471 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag K4L01_RS10090 Protein ID WP_260098719.1
Coordinates 2100468..2100719 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4L01_RS10075 (K4L01_10055) 2096296..2097168 - 873 WP_260098716.1 hypothetical protein -
K4L01_RS10080 (K4L01_10060) 2097165..2099960 - 2796 WP_260098717.1 lactate dehydrogenase -
K4L01_RS10085 (K4L01_10065) 2100202..2100471 - 270 WP_260098718.1 Txe/YoeB family addiction module toxin Toxin
K4L01_RS10090 (K4L01_10070) 2100468..2100719 - 252 WP_260098719.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K4L01_RS10095 (K4L01_10075) 2100873..2101505 - 633 WP_260098720.1 tyrosine-type recombinase/integrase -
K4L01_RS10100 (K4L01_10080) 2101802..2101999 + 198 WP_260098721.1 hypothetical protein -
K4L01_RS10105 (K4L01_10085) 2102396..2102866 + 471 WP_014875014.1 DUF2852 domain-containing protein -
K4L01_RS10110 (K4L01_10090) 2102992..2103423 + 432 WP_260098722.1 RDD family protein -
K4L01_RS10115 (K4L01_10095) 2103638..2104459 + 822 WP_014875016.1 arginyltransferase -
K4L01_RS10120 (K4L01_10100) 2104464..2104847 + 384 WP_061047839.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10307.69 Da        Isoelectric Point: 9.8059

>T212754 WP_260098718.1 NZ_CP081257:c2100471-2100202 [Phaeobacter inhibens]
VKLVFSDNAWEDYLWWQSPGNEKGLDRVNELLKAAGRMPFKGIGKPEPLKGDLSGWWSRRITAEHRFVYRVSGKGDGQSL
EIAQLRYHY

Download         Length: 270 bp

>T212754 NZ_CP107346:56133-56444 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9384.60 Da        Isoelectric Point: 5.0608

>AT212754 WP_260098719.1 NZ_CP081257:c2100719-2100468 [Phaeobacter inhibens]
MDVITYTDARASLKDVMDRVIHDNVDVVVTRKKREAVVMMSLDEYNAIQETLHLQRSPANARRLQSSIAQLDAGNGTERD
IDL

Download         Length: 252 bp

>AT212754 NZ_CP107346:56441-56860 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References