Detailed information of TA system TA212692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4738966..4739720
• Replicon: chromosome
• Accession: NZ_CP081189
• Organism: Salmonella enterica strain sg1722-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: K4F90_RS23075
• Protein ID: WP_000558166.1
• Coordinates: 4738966..4739277 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K4F90_RS23080
• Protein ID: WP_001259011.1
• Coordinates: 4739274..4739720 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4F90_RS23045 (4734624)	4734624..4735526	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K4F90_RS23050 (4735523)	4735523..4736158	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K4F90_RS23055 (4736155)	4736155..4737084	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K4F90_RS23060 (4737131)	4737131..4737421	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
K4F90_RS23065 (4737422)	4737422..4737733	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
K4F90_RS23070 (4737951)	4737951..4738880	+	930	WP_001127703.1	alpha/beta hydrolase	-
K4F90_RS23075 (4738966)	4738966..4739277	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
K4F90_RS23080 (4739274)	4739274..4739720	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
K4F90_RS23085 (4739735)	4739735..4740676	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K4F90_RS23090 (4740721)	4740721..4741158	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K4F90_RS23095 (4741155)	4741155..4742027	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K4F90_RS23100 (4742021)	4742021..4742620	-	600	WP_000965695.1	glucose-1-phosphatase	-
K4F90_RS23105 (4742811)	4742811..4743614	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
K4F90_RS23110 (4743648)	4743648..4744544	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T212692 WP_000558166.1 NZ_CP081189:4738966-4739277 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T212692 NZ_CP107327:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT212692 WP_001259011.1 NZ_CP081189:4739274-4739720 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT212692 NZ_CP107327:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90