Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4775209..4775811 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag K4F82_RS23210 Protein ID WP_001159630.1
Coordinates 4775500..4775811 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K4F82_RS23205 Protein ID WP_000362050.1
Coordinates 4775209..4775499 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS23190 (4772702) 4772702..4773604 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K4F82_RS23195 (4773601) 4773601..4774236 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K4F82_RS23200 (4774233) 4774233..4775162 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K4F82_RS23205 (4775209) 4775209..4775499 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
K4F82_RS23210 (4775500) 4775500..4775811 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
K4F82_RS23215 (4776029) 4776029..4776958 + 930 WP_001127703.1 alpha/beta hydrolase -
K4F82_RS23220 (4777044) 4777044..4777355 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
K4F82_RS23225 (4777352) 4777352..4777798 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
K4F82_RS23230 (4777813) 4777813..4778754 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K4F82_RS23235 (4778799) 4778799..4779236 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
K4F82_RS23240 (4779233) 4779233..4780105 - 873 WP_000921427.1 virulence factor BrkB family protein -
K4F82_RS23245 (4780099) 4780099..4780698 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T212667 WP_001159630.1 NZ_CP081187:c4775811-4775500 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T212667 NZ_CP107313:c74962-74813 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT212667 WP_000362050.1 NZ_CP081187:c4775499-4775209 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT212667 NZ_CP107313:75007-75066 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References