212659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2442846..2443368 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K4F82_RS11865 Protein ID WP_000221343.1
Coordinates 2443084..2443368 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K4F82_RS11860 Protein ID WP_000885424.1
Coordinates 2442846..2443094 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS11840 (2438073) 2438073..2439539 + 1467 WP_000987828.1 hypothetical protein -
K4F82_RS11845 (2440347) 2440347..2441061 + 715 Protein_2325 helix-turn-helix domain-containing protein -
K4F82_RS11850 (2441117) 2441117..2442025 - 909 WP_010989018.1 hypothetical protein -
K4F82_RS11855 (2442168) 2442168..2442500 - 333 WP_000253154.1 DUF1493 family protein -
K4F82_RS11860 (2442846) 2442846..2443094 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K4F82_RS11865 (2443084) 2443084..2443368 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K4F82_RS11870 (2443539) 2443539..2443928 + 390 WP_000194089.1 RidA family protein -
K4F82_RS11875 (2443980) 2443980..2445059 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K4F82_RS11880 (2445252) 2445252..2445740 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K4F82_RS11885 (2445785) 2445785..2447293 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2438076..2450150 12074


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T212659 WP_000221343.1 NZ_CP081187:2443084-2443368 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T212659 NZ_CP107312:c2194366-2194082 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT212659 WP_000885424.1 NZ_CP081187:2442846-2443094 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT212659 NZ_CP107312:c2194598-2194356 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References