Detailed information of TA system TA212641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2531491..2532145
• Replicon: chromosome
• Accession: NZ_CP081178
• Organism: Pseudomonas mandelii strain KGI_MA19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: K3369_RS11320
• Protein ID: WP_010458844.1
• Coordinates: 2531795..2532145 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A024E6Q4
• Locus tag: K3369_RS11315
• Protein ID: WP_010458842.1
• Coordinates: 2531491..2531805 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3369_RS11300 (K3369_11300)	2529210..2529410	+	201	WP_010458836.1	co-regulatory protein PtrA N-terminal domain-containing protein	-
K3369_RS11305 (K3369_11305)	2529490..2529822	+	333	WP_221109013.1	DUF2790 domain-containing protein	-
K3369_RS11310 (K3369_11310)	2529991..2531316	-	1326	WP_221109014.1	OprD family porin	-
K3369_RS11315 (K3369_11315)	2531491..2531805	-	315	WP_010458842.1	XRE family transcriptional regulator	Antitoxin
K3369_RS11320 (K3369_11320)	2531795..2532145	-	351	WP_010458844.1	toxin	Toxin
K3369_RS11325 (K3369_11325)	2532434..2533897	-	1464	WP_010458846.1	NADH-quinone oxidoreductase subunit NuoN	-
K3369_RS11330 (K3369_11330)	2533905..2535437	-	1533	WP_010458848.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13976.75 Da
• Isoelectric Point: 7.1657

>T212641 WP_010458844.1 NZ_CP081178:c2532145-2531795 [Pseudomonas mandelii]
MDALFIELRMFQKHRDEYLDDDLFRSFQLELLKNPEAGDLIEGTGGLRKIRFCDQRRGKGKRGGLRVIYYWWSGFDQFWL
FTVYSKNEQDDLSPSQKNIFRQALDREINTRSHYET

Nucleotide

• Length: 351 bp

>T212641 NZ_CP107307:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11972.96 Da
• Isoelectric Point: 9.9896

>AT212641 WP_010458842.1 NZ_CP081178:c2531805-2531491 [Pseudomonas mandelii]
MKRDIFSELMDGLEALAEERQGKITLRTHKVQLPKLMPITAEEVVAIRQQLNLSRPVFAMYLRTNTRTLENWEQGRAIPN
AQATTLIRLVERFPQTIEQLAALT

Nucleotide

• Length: 315 bp

>AT212641 NZ_CP107307:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A024E6Q4