Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 924677..925497 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag K2O50_RS04320 Protein ID WP_050704327.1
Coordinates 924677..925174 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A8I0D4S5
Locus tag K2O50_RS04325 Protein ID WP_050704328.1
Coordinates 925171..925497 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS04300 (K2O50_04300) 919871..921397 + 1527 WP_050704324.1 efflux transporter outer membrane subunit -
K2O50_RS04305 (K2O50_04305) 921394..923571 + 2178 WP_050704325.1 FUSC family protein -
K2O50_RS04310 (K2O50_04310) 923561..923761 + 201 WP_028689551.1 DUF1656 domain-containing protein -
K2O50_RS04315 (K2O50_04315) 923772..924632 + 861 WP_050704326.1 HlyD family secretion protein -
K2O50_RS04320 (K2O50_04320) 924677..925174 - 498 WP_050704327.1 type II toxin-antitoxin system YhaV family toxin Toxin
K2O50_RS04325 (K2O50_04325) 925171..925497 - 327 WP_050704328.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
K2O50_RS04330 (K2O50_04330) 925607..926053 - 447 WP_052896297.1 universal stress protein -
K2O50_RS04335 (K2O50_04335) 926295..927200 + 906 WP_050704330.1 LysR family transcriptional regulator -
K2O50_RS04340 (K2O50_04340) 927416..928957 + 1542 WP_050704331.1 MFS transporter -
K2O50_RS04345 (K2O50_04345) 928985..930046 + 1062 WP_050704332.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 19072.83 Da        Isoelectric Point: 10.1768

>T212587 WP_050704327.1 NZ_CP081016:c925174-924677 [Pseudomonas sp. 2hn]
MTETRRKPLCVHGWSVFAHPLFLDKLEALIDEVEVLQKKDPVGYVKKNAAKRLKAVRRLAFDVIAQAPGNPDHRMGGTLG
AEHKHWFRAKFFQQYRLFYRYHASSKIIVLAWVNDDDSKRAYESSDDAYKVFRRMLGSGHPPDDWDQLLQEATAATARFN
ATLKR

Download         Length: 498 bp

>T212587 NZ_CP107285:c53952-53674 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11997.46 Da        Isoelectric Point: 4.2522

>AT212587 WP_050704328.1 NZ_CP081016:c925497-925171 [Pseudomonas sp. 2hn]
MATTFEAESTLTERYQTTVPETVRRALGLKKRDKIHYSIRPDGAVILTRAETAEEDPAVGQFLDFLARDIATNPQRLKVV
DAELVARLDALVGDVEIDLDQPLSADDE

Download         Length: 327 bp

>AT212587 NZ_CP107285:c54221-53952 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References