Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 446188..446792 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K2O50_RS02075 Protein ID WP_050703499.1
Coordinates 446188..446502 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K2O50_RS02080 Protein ID WP_050703537.1
Coordinates 446502..446792 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS02045 (K2O50_02045) 441439..441900 - 462 WP_050703496.1 Lrp/AsnC family transcriptional regulator -
K2O50_RS02050 (K2O50_02050) 442057..442752 + 696 WP_050703497.1 CatB-related O-acetyltransferase -
K2O50_RS02055 (K2O50_02055) 442807..443178 - 372 WP_046857393.1 hypothetical protein -
K2O50_RS02060 (K2O50_02060) 443630..444766 + 1137 WP_050703498.1 RNA ligase RtcB family protein -
K2O50_RS02065 (K2O50_02065) 444766..445386 + 621 WP_050703536.1 peptide chain release factor H -
K2O50_RS02070 (K2O50_02070) 445501..445944 + 444 WP_156329572.1 hypothetical protein -
K2O50_RS02075 (K2O50_02075) 446188..446502 + 315 WP_050703499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2O50_RS02080 (K2O50_02080) 446502..446792 + 291 WP_050703537.1 helix-turn-helix domain-containing protein Antitoxin
K2O50_RS02085 (K2O50_02085) 446906..447094 - 189 WP_050703500.1 hypothetical protein -
K2O50_RS02095 (K2O50_02095) 447750..451493 - 3744 WP_050703501.1 bifunctional diguanylate cyclase/phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11991.65 Da        Isoelectric Point: 8.4390

>T212585 WP_050703499.1 NZ_CP081016:446188-446502 [Pseudomonas sp. 2hn]
MIFVETSIFTEDLHELLSDDEYRAFQQHLAVNPTAGDVIQHTGGLRKIRWAANGKGKRGGVRVIYYYITAAAQIRLLVIY
RKGVKDDLSEDERKELRKLNEGWQ

Download         Length: 315 bp

>T212585 NZ_CP107284:c4424828-4424478 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10822.31 Da        Isoelectric Point: 10.1734

>AT212585 WP_050703537.1 NZ_CP081016:446502-446792 [Pseudomonas sp. 2hn]
MEKGLFNRLKESMTQMNEIDRGERQPSREFHVDAVQVKNIRKATGLSQIAFAETIDVAVGTLRNWEQGRRDPEGPARALL
RAIHNDPANVLAALKQ

Download         Length: 291 bp

>AT212585 NZ_CP107284:c4425073-4424822 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References