Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 130855..131410 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag K2O50_RS00620 Protein ID WP_256205947.1
Coordinates 130855..131112 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F7XUM4
Locus tag K2O50_RS00625 Protein ID WP_046853585.1
Coordinates 131126..131410 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS00600 (K2O50_00600) 126018..127583 + 1566 WP_050703162.1 SulP family inorganic anion transporter -
K2O50_RS00605 (K2O50_00605) 127902..128726 - 825 WP_050703161.1 shikimate dehydrogenase -
K2O50_RS00610 (K2O50_00610) 128752..129663 - 912 WP_050703160.1 oxygen-dependent coproporphyrinogen oxidase -
K2O50_RS00615 (K2O50_00615) 129796..130773 + 978 WP_050703159.1 NADPH:quinone reductase -
K2O50_RS00620 (K2O50_00620) 130855..131112 - 258 WP_256205947.1 Txe/YoeB family addiction module toxin Toxin
K2O50_RS00625 (K2O50_00625) 131126..131410 - 285 WP_046853585.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K2O50_RS00630 (K2O50_00630) 131690..132001 - 312 WP_050703158.1 hypothetical protein -
K2O50_RS00635 (K2O50_00635) 132433..132699 - 267 WP_256205946.1 hypothetical protein -
K2O50_RS00640 (K2O50_00640) 132756..133952 + 1197 WP_016391483.1 IS256 family transposase -
K2O50_RS00645 (K2O50_00645) 134637..134915 + 279 WP_050703243.1 HigA family addiction module antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 121912..132699 10787
- flank IS/Tn - - 132756..133952 1196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10011.27 Da        Isoelectric Point: 6.8512

>T212582 WP_256205947.1 NZ_CP081016:c131112-130855 [Pseudomonas sp. 2hn]
VSVAFTAEGWEDYHHWREADSAIFETVNVLIRECCRTPFKGTGKPEPLKGDLSGFWSRRITREHRLVYFYEGGQLTVLQC
RFHYD

Download         Length: 258 bp

>T212582 NZ_CP107284:4191512-4191664 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.02 Da        Isoelectric Point: 4.8258

>AT212582 WP_046853585.1 NZ_CP081016:c131410-131126 [Pseudomonas sp. 2hn]
MHVLTFSQARADLKQTMDDVCRDHEPAIITRQRGEPVVMLSLEDYNGMQETLYLLGSSANARRLRSSVEQLRSGQPVTQE
LIIDEHEVKATQQD

Download         Length: 285 bp

>AT212582 NZ_CP107284:c4191463-4191406 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7XUM4

References