Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4268799..4269057 Replicon chromosome
Accession NZ_CP081010
Organism Escherichia coli strain 25POL

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag K3072_RS20530 Protein ID WP_000809168.1
Coordinates 4268905..4269057 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4268799..4268856 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3072_RS20515 4264628..4265887 - 1260 WP_000494928.1 hypothetical protein -
K3072_RS20520 4266016..4267509 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
K3072_RS20525 4267529..4268290 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4268799..4268856 - 58 - - Antitoxin
K3072_RS20530 4268905..4269057 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
K3072_RS20535 4269162..4270292 - 1131 WP_001118465.1 molecular chaperone DnaJ -
K3072_RS20540 4270381..4272297 - 1917 WP_000516135.1 molecular chaperone DnaK -
K3072_RS20545 4272669..4273073 + 405 WP_000843687.1 DUF2541 family protein -
K3072_RS20550 4273099..4273812 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T212574 WP_000809168.1 NZ_CP081010:4268905-4269057 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T212574 NZ_CP107284:2042300-2042403 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT212574 NZ_CP081010:c4268856-4268799 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References