Detailed information of TA system TA212550

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4532428..4532648
• Replicon: chromosome
• Accession: NZ_CP081009
• Organism: Escherichia coli strain Stbl4

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: D3H2K1
• Locus tag: K3830_RS22095
• Protein ID: WP_000170955.1
• Coordinates: 4532428..4532535 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4532582..4532648 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3830_RS22045	4527452..4528147	+	696	Protein_4337	IS3-like element IS2 family transposase	-
K3830_RS22375	4528837..4530084	+	1248	Protein_4338	tail fiber protein	-
K3830_RS22060	4530051..4530614	-	564	WP_220717925.1	DNA-packaging protein	-
K3830_RS22075	4531140..4531550	-	411	Protein_4340	RHS repeat protein	-
K3830_RS22080	4531548..4531955	+	408	Protein_4341	hypothetical protein	-
K3830_RS22085	4531949..4532050	+	102	Protein_4342	DNA-packaging protein	-
K3830_RS22090	4532007..4532339	+	333	Protein_4343	hypothetical protein	-
K3830_RS22095	4532428..4532535	-	108	WP_000170955.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4532582..4532648	+	67	-	-	Antitoxin
K3830_RS22100	4532784..4532936	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	-
K3830_RS22380	4533757..4534086	-	330	Protein_4346	hypothetical protein	-
K3830_RS22110	4534423..4534737	-	315	Protein_4347	hypothetical protein	-
K3830_RS22385	4535051..4535661	+	611	Protein_4348	RHS element protein	-
K3830_RS22130	4535680..4535952	+	273	Protein_4349	ISAs1 family transposase	-
K3830_RS22140	4536741..4536977	-	237	Protein_4350	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4013.82 Da
• Isoelectric Point: 11.4779

>T212550 WP_000170955.1 NZ_CP081009:c4532535-4532428 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T212550 NZ_CP107268:c1414054-1413716 [Coxiella burnetii]
TTGCCTCTTACGCTGTATATTATGCTTGATGTAACGCGTAAAACTGTTATCCTTGAAGTGATGATAAAAAGTTTCAAGGA
CAAATACACTAAATATTTATATGAAGGTGTATCCGTTTCAAAATGGCAAGCCATACGAAAGCAGGCGGAAAGACGGCTTC
AGATTTTGGATTCAGTGACATCGTTAGATGATTTGAGAAGTTTGCCAAGCAATCGTTTTGAATCGTTGCGGGGGAATAGA
AAAGGACAATTTAGTATAAGGATTAATAAGCAATGGCGCATTTGTTTTAAGTGGATTAACAATGAGCCAACTGAAGTTGA
AATTGTGGATTATCATTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT212550 NZ_CP081009:4532582-4532648 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A829J2A9

Antitoxin