Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4031436..4032043 Replicon chromosome
Accession NC_007413
Organism Anabaena variabilis ATCC 29413 (Anabaena flos-aquae UTEX 1444)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AVA_RS16420 Protein ID WP_011319973.1
Coordinates 4031436..4031720 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AVA_RS16425 Protein ID WP_011319974.1
Coordinates 4031735..4032043 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVA_RS16405 4026735..4029578 + 2844 WP_011319969.1 DUF3987 domain-containing protein -
AVA_RS30490 4029657..4029812 + 156 WP_011319970.1 hypothetical protein -
AVA_RS16410 4029980..4030567 + 588 WP_011319971.1 hypothetical protein -
AVA_RS16415 4030787..4031218 - 432 WP_011319972.1 hypothetical protein -
AVA_RS16420 4031436..4031720 + 285 WP_011319973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AVA_RS16425 4031735..4032043 + 309 WP_011319974.1 HigA family addiction module antidote protein Antitoxin
AVA_RS16430 4032072..4034471 - 2400 WP_011319975.1 NACHT domain-containing NTPase -
AVA_RS16435 4034628..4034852 - 225 WP_153228420.1 hypothetical protein -
AVA_RS16440 4034959..4035888 + 930 WP_011319977.1 caspase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10826.24 Da        Isoelectric Point: 5.0914

>T21255 WP_011319973.1 NC_007413:4031436-4031720 [Trichormus variabilis ATCC 29413]
VIVNFKSEETKLIFEGFTSSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLVGDRSGQYSIRINDQWRICFVWT
DENNASEVEIVDYH

Download         Length: 285 bp

>T21255 NC_007413:4031436-4031720 [Trichormus variabilis ATCC 29413]
GTGATTGTTAATTTCAAGTCTGAAGAGACAAAGCTAATTTTTGAAGGCTTTACATCTTCTCAATACCCACCCAATATTCA
GAAGACTGCTTTACGAAAACTACTTATCCTTGATGCAGCAACATCAATTAATGACTTACGCGTCCCACCAGGAAATCGCC
TAGAAAAGCTAGTTGGCGATAGAAGTGGCCAGTACAGTATTCGGATTAATGACCAATGGCGGATTTGCTTTGTTTGGACA
GATGAAAACAATGCTTCGGAAGTTGAAATAGTCGATTACCACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11699.17 Da        Isoelectric Point: 5.6642

>AT21255 WP_011319974.1 NC_007413:4031735-4032043 [Trichormus variabilis ATCC 29413]
MNNNRLPNIHPGEILKLDFLEPLNITAYRLSKDIGVTQTRISEILSGKRSITADTALRLSHYFGNTAQFWLNLQTQYDLR
QALEENSEVYNQISKFLSDDVA

Download         Length: 309 bp

>AT21255 NC_007413:4031735-4032043 [Trichormus variabilis ATCC 29413]
ATGAATAACAACCGTTTGCCAAACATTCATCCAGGTGAAATCCTAAAACTAGACTTTTTAGAACCGTTGAATATCACAGC
TTATCGATTAAGCAAAGATATAGGTGTAACTCAGACACGAATTAGTGAAATTTTATCTGGAAAACGGAGTATTACGGCTG
ATACAGCTTTGCGTCTATCCCACTATTTTGGCAACACCGCCCAGTTTTGGTTAAATTTACAAACACAATATGATTTACGT
CAAGCCCTTGAAGAAAATTCAGAAGTTTATAATCAAATTTCTAAATTTCTGTCTGATGATGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References