Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4031436..4032043 Replicon chromosome
Accession NC_007413
Organism Anabaena variabilis ATCC 29413 (Anabaena flos-aquae UTEX 1444)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AVA_RS16420 Protein ID WP_011319973.1
Coordinates 4031436..4031720 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AVA_RS16425 Protein ID WP_011319974.1
Coordinates 4031735..4032043 (+) Length 103 a.a.

Genomic Context

AVA_RS16405AVA_RS30490AVA_RS16410AVA_RS16420AVA_RS16425AVA_RS16440AVA_RS16415AVA_RS16430AVA_RS16435
Location: 4026735..4029578 (2844 bp)
Type: Others
Protein ID: WP_011319969.1
Location: 4029657..4029812 (156 bp)
Type: Others
Protein ID: WP_011319970.1
Location: 4029980..4030567 (588 bp)
Type: Others
Protein ID: WP_011319971.1
Location: 4031436..4031720 (285 bp)
Type: Toxin
Protein ID: WP_011319973.1
Location: 4031735..4032043 (309 bp)
Type: Antitoxin
Protein ID: WP_011319974.1
Location: 4034959..4035888 (930 bp)
Type: Others
Protein ID: WP_011319977.1
Location: 4030787..4031218 (432 bp)
Type: Others
Protein ID: WP_011319972.1
Location: 4032072..4034471 (2400 bp)
Type: Others
Protein ID: WP_011319975.1
Location: 4034628..4034852 (225 bp)
Type: Others
Protein ID: WP_153228420.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AVA_RS164054026735..4029578+2844WP_011319969.1DUF3987 domain-containing protein-
AVA_RS304904029657..4029812+156WP_011319970.1hypothetical protein-
AVA_RS164104029980..4030567+588WP_011319971.1hypothetical protein-
AVA_RS164154030787..4031218-432WP_011319972.1hypothetical protein-
AVA_RS164204031436..4031720+285WP_011319973.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AVA_RS164254031735..4032043+309WP_011319974.1HigA family addiction module antidote proteinAntitoxin
AVA_RS164304032072..4034471-2400WP_011319975.1NACHT domain-containing NTPase-
AVA_RS164354034628..4034852-225WP_153228420.1hypothetical protein-
AVA_RS164404034959..4035888+930WP_011319977.1caspase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10826.24 Da        Isoelectric Point: 5.0914

>T21255 WP_011319973.1 NC_007413:4031436-4031720 [Trichormus variabilis ATCC 29413]
VIVNFKSEETKLIFEGFTSSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLVGDRSGQYSIRINDQWRICFVWT
DENNASEVEIVDYH

Download         Length: 285 bp

>T21255 NC_007413:4031436-4031720 [Trichormus variabilis ATCC 29413]
GTGATTGTTAATTTCAAGTCTGAAGAGACAAAGCTAATTTTTGAAGGCTTTACATCTTCTCAATACCCACCCAATATTCA
GAAGACTGCTTTACGAAAACTACTTATCCTTGATGCAGCAACATCAATTAATGACTTACGCGTCCCACCAGGAAATCGCC
TAGAAAAGCTAGTTGGCGATAGAAGTGGCCAGTACAGTATTCGGATTAATGACCAATGGCGGATTTGCTTTGTTTGGACA
GATGAAAACAATGCTTCGGAAGTTGAAATAGTCGATTACCACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11699.17 Da        Isoelectric Point: 5.6642

>AT21255 WP_011319974.1 NC_007413:4031735-4032043 [Trichormus variabilis ATCC 29413]
MNNNRLPNIHPGEILKLDFLEPLNITAYRLSKDIGVTQTRISEILSGKRSITADTALRLSHYFGNTAQFWLNLQTQYDLR
QALEENSEVYNQISKFLSDDVA

Download         Length: 309 bp

>AT21255 NC_007413:4031735-4032043 [Trichormus variabilis ATCC 29413]
ATGAATAACAACCGTTTGCCAAACATTCATCCAGGTGAAATCCTAAAACTAGACTTTTTAGAACCGTTGAATATCACAGC
TTATCGATTAAGCAAAGATATAGGTGTAACTCAGACACGAATTAGTGAAATTTTATCTGGAAAACGGAGTATTACGGCTG
ATACAGCTTTGCGTCTATCCCACTATTTTGGCAACACCGCCCAGTTTTGGTTAAATTTACAAACACAATATGATTTACGT
CAAGCCCTTGAAGAAAATTCAGAAGTTTATAATCAAATTTCTAAATTTCTGTCTGATGATGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References