Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 3912917..3913419 | Replicon | chromosome |
| Accession | NZ_CP081009 | ||
| Organism | Escherichia coli strain Stbl4 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | K3830_RS18750 | Protein ID | WP_000767829.1 |
| Coordinates | 3912917..3913171 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | K3830_RS18755 | Protein ID | WP_001259255.1 |
| Coordinates | 3913168..3913419 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3830_RS18720 (3907932) | 3907932..3908159 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| K3830_RS18725 (3908173) | 3908173..3909231 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| K3830_RS18730 (3909410) | 3909410..3910768 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| K3830_RS18735 (3910758) | 3910758..3910820 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| K3830_RS18740 (3911035) | 3911035..3911964 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| K3830_RS18745 (3912010) | 3912010..3912834 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| K3830_RS18750 (3912917) | 3912917..3913171 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| K3830_RS18755 (3913168) | 3913168..3913419 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| K3830_RS18760 (3913702) | 3913702..3913752 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| K3830_RS18765 (3913898) | 3913898..3914797 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| K3830_RS18770 (3914803) | 3914803..3916107 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| K3830_RS18775 (3916104) | 3916104..3917174 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| K3830_RS18780 (3917174) | 3917174..3918241 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T212539 WP_000767829.1 NZ_CP081009:c3913171-3912917 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T212539 NZ_CP107262:2192072-2192488 [Leclercia adecarboxylata]
GTGATCAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGTGAGCAGCCCGAAGCTGTCATTAAACGGCT
GGAGCAGGCAGTGCTGCGGAATAACCGAATCGTGGTTTCGGCCATTACCTATGCCGAAATGCGTTTCGGTGCAATCGGAA
AAAAGGCATCCCCCCGCCACGGCATGCTTGTCGAAGCATTCTGCGCCCGCCTTGATGCAATCCTCGCCTGGGACCGCGCC
GCGGTGGACGCAACTACGGAGATTAAGGCAGCACTGACTGCGGCCGGGACGCCAATCGGTCCGAACGATACGGCGATCGC
CGGGCATGCCATCGCCGCCGGCGCCGTGCTGGTGACGAACAACGTGCGAGAGTTTGAGCGTGTGCCTGGCCTGGTTCTGG
AAGACTGGGCTAACTGA
GTGATCAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGTGAGCAGCCCGAAGCTGTCATTAAACGGCT
GGAGCAGGCAGTGCTGCGGAATAACCGAATCGTGGTTTCGGCCATTACCTATGCCGAAATGCGTTTCGGTGCAATCGGAA
AAAAGGCATCCCCCCGCCACGGCATGCTTGTCGAAGCATTCTGCGCCCGCCTTGATGCAATCCTCGCCTGGGACCGCGCC
GCGGTGGACGCAACTACGGAGATTAAGGCAGCACTGACTGCGGCCGGGACGCCAATCGGTCCGAACGATACGGCGATCGC
CGGGCATGCCATCGCCGCCGGCGCCGTGCTGGTGACGAACAACGTGCGAGAGTTTGAGCGTGTGCCTGGCCTGGTTCTGG
AAGACTGGGCTAACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT212539 WP_001259255.1 NZ_CP081009:c3913419-3913168 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT212539 NZ_CP107262:2191845-2192075 [Leclercia adecarboxylata]
ATGAGAACCGTATCGATTTTCAAAAATGGCAATAATCGCGCCATTCGTCTGCCCCGTGACCTGGATTTTGAGGGAGTTAG
CGAACTGGAGATCGTCCGGGAAGGTGACAGCATCATCCTTCGTCCCGTTCGCCCAACATGGGGTTCGTTTACTCAGCTCG
AAAAAGCCGATTCGGACTTTATGGCCGAGCGTGGGGACGTCGTCAGCGATGAAGGAAGGTTTGACCTGTGA
ATGAGAACCGTATCGATTTTCAAAAATGGCAATAATCGCGCCATTCGTCTGCCCCGTGACCTGGATTTTGAGGGAGTTAG
CGAACTGGAGATCGTCCGGGAAGGTGACAGCATCATCCTTCGTCCCGTTCGCCCAACATGGGGTTCGTTTACTCAGCTCG
AAAAAGCCGATTCGGACTTTATGGCCGAGCGTGGGGACGTCGTCAGCGATGAAGGAAGGTTTGACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|