212533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3175285..3175978 Replicon chromosome
Accession NZ_CP081009
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K3830_RS15060 Protein ID WP_000415584.1
Coordinates 3175285..3175581 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K3830_RS15065 Protein ID WP_000650107.1
Coordinates 3175583..3175978 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3830_RS15025 (3170373) 3170373..3170687 - 315 WP_000958598.1 putative quinol monooxygenase -
K3830_RS15030 (3170718) 3170718..3171299 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K3830_RS15035 (3171618) 3171618..3171950 + 333 WP_000917684.1 DUF2645 family protein -
K3830_RS15040 (3171996) 3171996..3173345 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K3830_RS15045 (3173342) 3173342..3174001 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
K3830_RS15050 (3174153) 3174153..3174545 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K3830_RS15055 (3174598) 3174598..3175080 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K3830_RS15060 (3175285) 3175285..3175581 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K3830_RS15065 (3175583) 3175583..3175978 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K3830_RS15070 (3176111) 3176111..3177718 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K3830_RS15075 (3177856) 3177856..3180114 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T212533 WP_000415584.1 NZ_CP081009:3175285-3175581 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T212533 NZ_CP107262:220155-221462 [Leclercia adecarboxylata]
ATGCGCGCTCAACGTCTGACTGTTGCCATGAATGGCGAAGTGGTGGGTACGCTGCATCGTGATGGCAGCGGCGCGATGTC
ATTTCAGTATGCGCCCGAGTGGCTGGCAGAGCCTGGCGCACGTGCCATTTCGCTCTCTTTGCCGCTCCAGCACGGGAGGA
TCCGCGGAAAGCAGGTCTTCAATTTTTTCAGCAACCTGTTGCCAGACTCAGAGGCGATAATCGCCCGCATGCAGGCCCGT
TTTCAGGTTGAGACGGCACATCCCTTTGATCTGCTCGCCAGTGTCGGACGAGACTGCGTGGGTGCCATTCAGCTCTATCC
ACCGGGGCTGGAGATCCCGTCGGTGATGGATATCGTCGCCGAACCGCTGGATGACGAGCAGATTGCTTCCTTGCTGGAGG
GTTACCAGATGGCCCCGTTAGGGATGAGCGAAGAGGGGGCTGATTTTCGCATTTCGCTGGCCGGGGCGCAGGAGAAAACG
GCGTTGCTATGGTATCAGGATCGCTGGCAGCGGCCTCAGGGTAGTACACCAACCAGCCATATATTCAAATTACCGATAGG
CAGAATAGAGCAGAACAATATCGATCTCAGCGAGAGCTGTGAAAACGAGTGGCTCTGCTTACGGATCGCAAAAGCCTTTG
GATTTCCGGTAGCGCATGCCGAAATGGCCACCTTTAGTCGCAAAAAAGTGCTGATTATTGAACGCTTCGATCGCCGTTGG
GCCCGCAGCGGGTGGCTGATGCGCCTGCCGCAGGAAGATTTTTGTCAGGCGCTGGGCATCGCTCCGGCACTGAAGTATGA
GTCCCACGGCGGGCCGGGCATCGCCGATGCCATGAAACTGCTGCTCGGTTCCCGCCTGGCAGCGCAGGATCGGGAGATGT
TCTTCAAAGCGCAGATCCTGTTCTGGATGCTGGCCGCGATTGATGGTCACGGTAAGAATTTCAGCCTGTTTATCGAAGCG
GACTCTTCGTTTCGCATGGCCCCGTTATACGATGTGATTTCGGCCTTTCCGCTGTTTGAGGCAGGGAGTATCCCGGCCAA
AAAAGCGAAGATGGCCATGGCATTACAGGGCAAAAACCGCCAGTACCATTTCGCGATGATCCAGCCGCGTCACTTTATCA
GTACCGCTGCGCACGCAGGCTTTTCGCAGGAGATCGCCCGGAGGCTGATGAAAGAGATGGCCGACCGCACGGATGAGGCG
ATCGCCACCGTCAGGGCGGAATTGCCAGCGGATTTTCCGGAACAGATAAGCGAGGCGATTTTCCGCGGTCTGGTAAGCCA
GGCGGCGAGAATAAGCCGCTTTGATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT212533 WP_000650107.1 NZ_CP081009:3175583-3175978 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT212533 NZ_CP107262:219900-220151 [Leclercia adecarboxylata]
ATGAAAGTGACCTCGGCAGGCGCACTGGCGCAGGCTGTCAAAGATCAGCGTAAGGTCAATAAGTTAACGCAATCGGAGAC
CGCTGAACAGGTTGGCATTAAACAAACCACGGTATCGGATTTCGAGAACAAACCTGAATCCACCAAGCTGGAAACCCTGT
TCAAAATTCTCTCAGCGCTGGATCTGGAACTTCATGTGGTGAAAAGAGGCTCGACGCTGCCCGATCATGCCAACTGGACA
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References