Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 3796404..3796906 | Replicon | chromosome |
| Accession | NZ_CP081008 | ||
| Organism | Escherichia coli strain XL10-gold-ultracompetent | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | K3831_RS18280 | Protein ID | WP_000767829.1 |
| Coordinates | 3796404..3796658 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | K3831_RS18285 | Protein ID | WP_001259255.1 |
| Coordinates | 3796655..3796906 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3831_RS18250 (3791419) | 3791419..3791646 | - | 228 | WP_046613325.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| K3831_RS18255 (3791660) | 3791660..3792718 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| K3831_RS18260 (3792897) | 3792897..3794255 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| K3831_RS18265 (3794245) | 3794245..3794307 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| K3831_RS18270 (3794522) | 3794522..3795451 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| K3831_RS18275 (3795497) | 3795497..3796321 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| K3831_RS18280 (3796404) | 3796404..3796658 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| K3831_RS18285 (3796655) | 3796655..3796906 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| K3831_RS18290 (3797189) | 3797189..3797239 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| K3831_RS18295 (3797385) | 3797385..3798284 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| K3831_RS18300 (3798290) | 3798290..3799594 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| K3831_RS18305 (3799591) | 3799591..3800661 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| K3831_RS18310 (3800661) | 3800661..3801728 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T212509 WP_000767829.1 NZ_CP081008:c3796658-3796404 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T212509 NZ_CP107241:c3142972-3142694 [Xanthomonas hortorum]
ATGATCCAGTCGTTTCGATGCAAGCACACACGCGCCTTGTTCGAAGGCGCTAGCCCGCGGCAATTCCGGTCCATGCAGGC
AGCGGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAATCGGCTTG
AGCTGTTGGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCTGGACTGAC
GCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA
ATGATCCAGTCGTTTCGATGCAAGCACACACGCGCCTTGTTCGAAGGCGCTAGCCCGCGGCAATTCCGGTCCATGCAGGC
AGCGGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAATCGGCTTG
AGCTGTTGGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCTGGACTGAC
GCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT212509 WP_001259255.1 NZ_CP081008:c3796906-3796655 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT212509 NZ_CP107241:c3142684-3142385 [Xanthomonas hortorum]
ATGCGACCCAACAACAAACTGCGCGCCATCCATCCCGGCGAAATACTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATCAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCGGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTACAGGCCACCTACGACCTG
AAGACCTTGCCCAACACAGGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG
ATGCGACCCAACAACAAACTGCGCGCCATCCATCCCGGCGAAATACTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATCAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCGGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTACAGGCCACCTACGACCTG
AAGACCTTGCCCAACACAGGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|