212500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2736757..2737450 Replicon chromosome
Accession NZ_CP081008
Organism Escherichia coli strain XL10-gold-ultracompetent

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K3831_RS13010 Protein ID WP_000415584.1
Coordinates 2736757..2737053 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K3831_RS13015 Protein ID WP_000650107.1
Coordinates 2737055..2737450 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3831_RS12975 (2731845) 2731845..2732159 - 315 WP_000958598.1 putative quinol monooxygenase -
K3831_RS12980 (2732190) 2732190..2732771 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K3831_RS12985 (2733090) 2733090..2733422 + 333 WP_000917684.1 DUF2645 family protein -
K3831_RS12990 (2733468) 2733468..2734817 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K3831_RS12995 (2734814) 2734814..2735473 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
K3831_RS13000 (2735625) 2735625..2736017 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K3831_RS13005 (2736070) 2736070..2736552 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K3831_RS13010 (2736757) 2736757..2737053 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K3831_RS13015 (2737055) 2737055..2737450 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K3831_RS13020 (2737583) 2737583..2739190 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K3831_RS13025 (2739328) 2739328..2741586 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T212500 WP_000415584.1 NZ_CP081008:2736757-2737053 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T212500 NZ_CP107108:c2097628-2097338 [Clostridioides difficile]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATCGAACTGCTGGAGCAGGTCGTAGCGTTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCACATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT212500 WP_000650107.1 NZ_CP081008:2737055-2737450 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT212500 NZ_CP107108:c2097903-2097625 [Clostridioides difficile]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References