Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3590141..3590834 Replicon chromosome
Accession NZ_CP081007
Organism Escherichia coli strain XL1-Blue

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K3826_RS17030 Protein ID WP_000415584.1
Coordinates 3590141..3590437 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K3826_RS17035 Protein ID WP_000650107.1
Coordinates 3590439..3590834 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3826_RS16995 (3585229) 3585229..3585543 - 315 WP_000958598.1 putative quinol monooxygenase -
K3826_RS17000 (3585574) 3585574..3586155 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K3826_RS17005 (3586474) 3586474..3586806 + 333 WP_000917684.1 DUF2645 family protein -
K3826_RS17010 (3586852) 3586852..3588201 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K3826_RS17015 (3588198) 3588198..3588857 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
K3826_RS17020 (3589009) 3589009..3589401 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K3826_RS17025 (3589454) 3589454..3589936 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K3826_RS17030 (3590141) 3590141..3590437 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K3826_RS17035 (3590439) 3590439..3590834 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K3826_RS17040 (3590967) 3590967..3592574 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K3826_RS17045 (3592712) 3592712..3594970 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T212464 WP_000415584.1 NZ_CP081007:3590141-3590437 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T212464 NZ_CP107040:c5174257-5173916 [Klebsiella oxytoca]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGC
ATGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATAACTTTGGCCGATGCCGTTAACTTTTTGGTAGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGATTC
AACTGGCAGGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT212464 WP_000650107.1 NZ_CP081007:3590439-3590834 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT212464 NZ_CP107040:c5174619-5174278 [Klebsiella oxytoca]
ATGAAATATACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGTCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATTACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGGCTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References