Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4334775..4335591 Replicon chromosome
Accession NZ_CP080958
Organism Citrobacter amalonaticus strain C3H

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3S7D6F0
Locus tag K1713_RS20915 Protein ID WP_042999109.1
Coordinates 4334775..4335251 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag K1713_RS20920 Protein ID WP_042999108.1
Coordinates 4335256..4335591 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1713_RS20895 (K1713_20895) 4329880..4330623 - 744 WP_044257300.1 molecular chaperone -
K1713_RS20900 (K1713_20900) 4330666..4333110 - 2445 WP_224267598.1 fimbria/pilus outer membrane usher protein -
K1713_RS20905 (K1713_20905) 4333204..4333752 - 549 WP_052443907.1 fimbrial protein -
K1713_RS20910 (K1713_20910) 4333821..4334351 - 531 WP_042999110.1 fimbrial protein -
K1713_RS20915 (K1713_20915) 4334775..4335251 - 477 WP_042999109.1 type II toxin-antitoxin system YhaV family toxin Toxin
K1713_RS20920 (K1713_20920) 4335256..4335591 - 336 WP_042999108.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
K1713_RS20925 (K1713_20925) 4335806..4336342 - 537 WP_192502108.1 ferredoxin-type protein NapF -
K1713_RS20930 (K1713_20930) 4336339..4336935 - 597 WP_054176702.1 molecular chaperone -
K1713_RS20935 (K1713_20935) 4336980..4337753 - 774 WP_044327723.1 dimethyl sulfoxide reductase anchor subunit -
K1713_RS20940 (K1713_20940) 4337746..4338372 - 627 WP_042999104.1 dimethylsulfoxide reductase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18237.84 Da        Isoelectric Point: 8.8956

>T212372 WP_042999109.1 NZ_CP080958:c4335251-4334775 [Citrobacter amalonaticus]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAKFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

>T212372 NZ_CP107004:3759975-3760253 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT212372 WP_042999108.1 NZ_CP080958:c4335591-4335256 [Citrobacter amalonaticus]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp

>AT212372 NZ_CP107004:3759712-3759972 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7D6F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DNJ3

References