Detailed information of TA system TA212357

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2507581..2507765
• Replicon: chromosome
• Accession: NZ_CP080770
• Organism: Staphylococcus aureus strain HL23187

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HLV54_RS12515
• Protein ID: WP_000482647.1
• Coordinates: 2507658..2507765 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2507581..2507641 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLV54_RS12495 (HLV54_002499)	2503091..2503258	-	168	WP_031845053.1	hypothetical protein	-
HLV54_RS12500 (HLV54_002500)	2503489..2505222	-	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
HLV54_RS12505 (HLV54_002501)	2505298..2507010	-	1713	WP_001064821.1	ABC transporter ATP-binding protein	-
HLV54_RS12510 (HLV54_002502)	2507464..2507631	-	168	WP_000301893.1	hypothetical protein	-
-	2507581..2507641	+	61	-	-	Antitoxin
HLV54_RS12515 (HLV54_002503)	2507658..2507765	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
HLV54_RS12520 (HLV54_002504)	2507898..2508284	-	387	WP_000779353.1	flippase GtxA	-
HLV54_RS12525 (HLV54_002505)	2508552..2509694	+	1143	WP_001176863.1	glycerate kinase	-
HLV54_RS12530 (HLV54_002506)	2509754..2510413	+	660	WP_000831298.1	membrane protein	-
HLV54_RS12535 (HLV54_002507)	2510596..2511807	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
HLV54_RS12540 (HLV54_002508)	2511930..2512403	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T212357 WP_000482647.1 NZ_CP080770:c2507765-2507658 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212357 NZ_CP107004:977325-977660 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT212357 NZ_CP080770:2507581-2507641 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin