Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1568455..1568869 Replicon chromosome
Accession NZ_CP080770
Organism Staphylococcus aureus strain HL23187

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HLV54_RS07420 Protein ID WP_001065099.1
Coordinates 1568618..1568869 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HLV54_RS07415 Protein ID WP_000028424.1
Coordinates 1568455..1568628 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLV54_RS07355 (HLV54_001471) 1564237..1564581 - 345 WP_000402904.1 hypothetical protein -
HLV54_RS07360 (HLV54_001472) 1564712..1565011 - 300 WP_000988330.1 HNH endonuclease -
HLV54_RS07365 (HLV54_001473) 1565243..1565659 - 417 WP_000590122.1 hypothetical protein -
HLV54_RS07370 (HLV54_001474) 1565687..1565887 - 201 WP_000265043.1 DUF1514 family protein -
HLV54_RS07375 (HLV54_001475) 1565887..1566537 - 651 WP_001005262.1 hypothetical protein -
HLV54_RS07380 (HLV54_001476) 1566696..1566845 - 150 WP_000237868.1 transcriptional activator RinB -
HLV54_RS07385 (HLV54_001477) 1566848..1567048 - 201 WP_001125015.1 hypothetical protein -
HLV54_RS07390 (HLV54_001478) 1567023..1567211 - 189 WP_000195782.1 DUF1381 domain-containing protein -
HLV54_RS07395 (HLV54_001479) 1567208..1567453 - 246 WP_001282074.1 hypothetical protein -
HLV54_RS07400 (HLV54_001480) 1567490..1567996 - 507 WP_001061834.1 dUTPase -
HLV54_RS07405 (HLV54_001481) 1568011..1568172 - 162 WP_000889683.1 hypothetical protein -
HLV54_RS07410 (HLV54_001482) 1568173..1568454 - 282 WP_000454994.1 hypothetical protein -
HLV54_RS07415 (HLV54_001483) 1568455..1568628 - 174 WP_000028424.1 hypothetical protein Antitoxin
HLV54_RS07420 (HLV54_001484) 1568618..1568869 - 252 WP_001065099.1 DUF1024 family protein Toxin
HLV54_RS07425 (HLV54_001485) 1568884..1569126 - 243 WP_000131388.1 phi PVL orf 51-like protein -
HLV54_RS07430 (HLV54_001486) 1569130..1569486 - 357 WP_000029366.1 SA1788 family PVL leukocidin-associated protein -
HLV54_RS07435 (HLV54_001487) 1569487..1569672 - 186 WP_001187236.1 DUF3113 family protein -
HLV54_RS07440 (HLV54_001488) 1569677..1570081 - 405 WP_000049798.1 DUF1064 domain-containing protein -
HLV54_RS07445 (HLV54_001489) 1570091..1570312 - 222 WP_001123669.1 DUF3269 family protein -
HLV54_RS07450 (HLV54_001490) 1570325..1570483 - 159 WP_000256594.1 hypothetical protein -
HLV54_RS07455 (HLV54_001491) 1570477..1571256 - 780 WP_000803062.1 ATP-binding protein -
HLV54_RS07460 (HLV54_001492) 1571266..1572036 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
HLV54_RS07465 (HLV54_001493) 1572102..1572383 + 282 WP_000414755.1 hypothetical protein -
HLV54_RS07470 (HLV54_001494) 1572376..1572525 - 150 WP_001081076.1 hypothetical protein -
HLV54_RS07475 (HLV54_001495) 1572522..1573196 - 675 WP_000057262.1 putative HNHc nuclease -
HLV54_RS07480 (HLV54_001496) 1573208..1573651 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1536900..1600729 63829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T212351 WP_001065099.1 NZ_CP080770:c1568869-1568618 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T212351 NZ_CP107003:c4215162-4214989 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT212351 WP_000028424.1 NZ_CP080770:c1568628-1568455 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT212351 NZ_CP107003:c4215486-4215190 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References