Detailed information of TA system TA212335

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2679996..2680220
• Replicon: chromosome
• Accession: NZ_CP080759
• Organism: Enterococcus faecalis strain M817

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: K2228_RS13215
• Protein ID: WP_224561205.1
• Coordinates: 2680119..2680220 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2679996..2680174 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2228_RS13190	2675643..2676596	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
K2228_RS13195	2676635..2677390	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
K2228_RS13200	2677387..2678352	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
K2228_RS13205	2678349..2679296	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
K2228_RS13210	2679481..2679933	+	453	WP_002378807.1	YueI family protein	-
-	2679996..2680174	+	179	-	-	Antitoxin
K2228_RS13215	2680119..2680220	-	102	WP_224561205.1	putative holin-like toxin	Toxin
K2228_RS13220	2680411..2682681	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
K2228_RS13225	2682852..2683358	+	507	WP_002378810.1	cysteine hydrolase family protein	-
K2228_RS13230	2683548..2684444	+	897	WP_002365354.1	YitT family protein	-
K2228_RS13235	2684495..2684893	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T212335 WP_224561205.1 NZ_CP080759:c2680220-2680119 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T212335 NZ_CP107003:c1123275-1122202 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT212335 NZ_CP080759:2679996-2680174 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin