Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3144451..3144959 Replicon chromosome
Accession NZ_CP080599
Organism Nocardiopsis sp. MT53

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag K1J57_RS14025 Protein ID WP_220564861.1
Coordinates 3144451..3144711 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag K1J57_RS14030 Protein ID WP_220564862.1
Coordinates 3144708..3144959 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1J57_RS14000 (K1J57_14000) 3139559..3140458 + 900 WP_220565528.1 transketolase -
K1J57_RS14005 (K1J57_14005) 3140670..3142448 + 1779 WP_220564857.1 ABC-F family ATP-binding cassette domain-containing protein -
K1J57_RS14010 (K1J57_14010) 3142465..3143349 - 885 WP_220564858.1 hypothetical protein -
K1J57_RS14015 (K1J57_14015) 3143397..3144065 - 669 WP_220564859.1 helix-turn-helix domain-containing protein -
K1J57_RS14020 (K1J57_14020) 3144219..3144446 + 228 WP_220564860.1 hypothetical protein -
K1J57_RS14025 (K1J57_14025) 3144451..3144711 - 261 WP_220564861.1 Txe/YoeB family addiction module toxin Toxin
K1J57_RS14030 (K1J57_14030) 3144708..3144959 - 252 WP_220564862.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K1J57_RS14035 (K1J57_14035) 3145100..3146044 - 945 WP_220565529.1 GDSL-type esterase/lipase family protein -
K1J57_RS14040 (K1J57_14040) 3146192..3146695 - 504 WP_220564863.1 MarR family transcriptional regulator -
K1J57_RS14045 (K1J57_14045) 3146774..3147424 - 651 WP_255647046.1 TetR/AcrR family transcriptional regulator -
K1J57_RS14050 (K1J57_14050) 3147439..3148386 - 948 WP_220564864.1 acyl-CoA desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10343.75 Da        Isoelectric Point: 10.0233

>T212266 WP_220564861.1 NZ_CP080599:c3144711-3144451 [Nocardiopsis sp. MT53]
VRLVWSQSAWEDYVWWQGQDRRILKRINALVKDIERNGNEGMGKPEPLRHGFQGYWSRRITDEHRLVYKLAGDEIRIAAC
RYHYGK

Download         Length: 261 bp

>T212266 NZ_CP107000:c1812379-1812005 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9392.52 Da        Isoelectric Point: 4.2403

>AT212266 WP_220564862.1 NZ_CP080599:c3144959-3144708 [Nocardiopsis sp. MT53]
MKTMSYTESRANYAATLDAVVNDREEVVITRAGHEPVVMMALSEYETLKETAYLLRSPENARRLVSAIEELESDQGIERE
LAE

Download         Length: 252 bp

>AT212266 NZ_CP107000:c1812836-1812468 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References