Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2894408..2895055 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name higB Uniprot ID A0A2S9UA56
Locus tag K2Y34_RS13670 Protein ID WP_004387788.1
Coordinates 2894708..2895055 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag K2Y34_RS13665 Protein ID WP_007776551.1
Coordinates 2894408..2894707 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS13635 (K2Y34_13595) 2889818..2890384 + 567 WP_004387793.1 DedA family protein -
K2Y34_RS13640 (K2Y34_13600) 2890381..2891154 - 774 WP_004387792.1 SDR family oxidoreductase -
K2Y34_RS13645 (K2Y34_13605) 2891327..2891410 + 84 WP_000691708.1 small membrane protein YohP -
K2Y34_RS13650 (K2Y34_13610) 2891447..2892406 - 960 WP_029464216.1 MBL fold metallo-hydrolase -
K2Y34_RS13655 (K2Y34_13615) 2892479..2893402 + 924 WP_015386496.1 LysR family transcriptional regulator -
K2Y34_RS13660 (K2Y34_13620) 2893405..2894337 - 933 WP_004387790.1 tRNA dihydrouridine(16) synthase DusC -
K2Y34_RS13665 (K2Y34_13625) 2894408..2894707 - 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
K2Y34_RS13670 (K2Y34_13630) 2894708..2895055 - 348 WP_004387788.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2Y34_RS13675 (K2Y34_13635) 2895308..2895709 + 402 WP_004387787.1 CidA/LrgA family protein -
K2Y34_RS13680 (K2Y34_13640) 2895706..2896401 + 696 WP_004387786.1 CidB/LrgB family autolysis modulator -
K2Y34_RS13685 (K2Y34_13645) 2896531..2897415 + 885 WP_004387785.1 cytidine deaminase -
K2Y34_RS13690 (K2Y34_13650) 2897540..2898253 + 714 WP_004387784.1 outer membrane permeability protein SanA -
K2Y34_RS13695 (K2Y34_13655) 2898753..2899763 - 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13457.72 Da        Isoelectric Point: 10.2057

>T212253 WP_004387788.1 NZ_CP080594:c2895055-2894708 [Cronobacter sakazakii]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHAGMKELRVQHAGRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRVADKLFSHYLNHREV

Download         Length: 348 bp

>T212253 NZ_CP106999:4032571-4032828 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT212253 WP_007776551.1 NZ_CP080594:c2894707-2894408 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT212253 NZ_CP106999:4032840-4033385 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UA56

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References