Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2116110..2116675 Replicon chromosome
Accession NZ_CP080594
Organism Cronobacter sakazakii strain Crono-684

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K2Y34_RS09915 Protein ID WP_004388463.1
Coordinates 2116110..2116388 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag K2Y34_RS09920 Protein ID WP_004388462.1
Coordinates 2116388..2116675 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2Y34_RS09900 (K2Y34_09875) 2111172..2113109 + 1938 WP_015386729.1 methyl-accepting chemotaxis protein -
K2Y34_RS09905 (K2Y34_09880) 2113218..2114204 + 987 WP_007888785.1 SDR family oxidoreductase -
K2Y34_RS09910 (K2Y34_09885) 2114206..2115810 - 1605 WP_004388464.1 alpha-amylase family protein -
K2Y34_RS09915 (K2Y34_09890) 2116110..2116388 + 279 WP_004388463.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2Y34_RS09920 (K2Y34_09895) 2116388..2116675 + 288 WP_004388462.1 HigA family addiction module antitoxin Antitoxin
K2Y34_RS09925 (K2Y34_09900) 2116729..2118846 - 2118 WP_004388461.1 TonB-dependent receptor PqqU -
K2Y34_RS09930 (K2Y34_09905) 2119124..2120182 + 1059 WP_004384961.1 YncE family protein -
K2Y34_RS09935 (K2Y34_09910) 2120212..2121078 - 867 WP_004384960.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10559.03 Da        Isoelectric Point: 10.0888

>T212243 WP_004388463.1 NZ_CP080594:2116110-2116388 [Cronobacter sakazakii]
MIRSFRHKGLQRYFETGSTAGIHARHARKISLRLAVLNQAISPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNYEDYH

Download         Length: 279 bp

>T212243 NZ_CP106999:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10428.03 Da        Isoelectric Point: 8.7791

>AT212243 WP_004388462.1 NZ_CP080594:2116388-2116675 [Cronobacter sakazakii]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFQA
RQSVDFSHLQRLQRA

Download         Length: 288 bp

>AT212243 NZ_CP106999:c1967319-1967048 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References