Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 2832006..2832653 | Replicon | chromosome |
| Accession | NZ_CP080591 | ||
| Organism | Cronobacter sakazakii strain Crono-589 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | K1721_RS13415 | Protein ID | WP_032988285.1 |
| Coordinates | 2832306..2832653 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | V5TYW5 |
| Locus tag | K1721_RS13410 | Protein ID | WP_007776551.1 |
| Coordinates | 2832006..2832305 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K1721_RS13375 (K1721_13360) | 2827416..2827982 | + | 567 | WP_032988289.1 | DedA family protein | - |
| K1721_RS13380 (K1721_13365) | 2827979..2828752 | - | 774 | WP_261001285.1 | SDR family oxidoreductase | - |
| K1721_RS13385 (K1721_13370) | 2828925..2829008 | + | 84 | WP_000691708.1 | small membrane protein YohP | - |
| K1721_RS13390 (K1721_13375) | 2829045..2829848 | - | 804 | WP_261001286.1 | MBL fold metallo-hydrolase | - |
| K1721_RS13395 | 2829873..2830004 | - | 132 | WP_261001287.1 | hypothetical protein | - |
| K1721_RS13400 (K1721_13380) | 2830077..2831000 | + | 924 | WP_014728497.1 | LysR family transcriptional regulator | - |
| K1721_RS13405 (K1721_13385) | 2831003..2831935 | - | 933 | WP_032988286.1 | tRNA dihydrouridine(16) synthase DusC | - |
| K1721_RS13410 (K1721_13390) | 2832006..2832305 | - | 300 | WP_007776551.1 | XRE family transcriptional regulator | Antitoxin |
| K1721_RS13415 (K1721_13395) | 2832306..2832653 | - | 348 | WP_032988285.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K1721_RS13420 (K1721_13400) | 2832906..2833307 | + | 402 | WP_032988284.1 | CidA/LrgA family protein | - |
| K1721_RS13425 (K1721_13405) | 2833304..2833999 | + | 696 | WP_007869369.1 | CidB/LrgB family autolysis modulator | - |
| K1721_RS13430 (K1721_13410) | 2834129..2835013 | + | 885 | WP_032988283.1 | cytidine deaminase | - |
| K1721_RS13435 (K1721_13415) | 2835138..2835851 | + | 714 | WP_004387784.1 | outer membrane permeability protein SanA | - |
| K1721_RS13440 (K1721_13420) | 2836358..2837368 | - | 1011 | WP_004387466.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13471.74 Da Isoelectric Point: 10.2057
>T212235 WP_032988285.1 NZ_CP080591:c2832653-2832306 [Cronobacter sakazakii]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHAGMKELRVQHAGRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRLADKLFSHYLNHREV
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHAGMKELRVQHAGRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRLADKLFSHYLNHREV
Download Length: 348 bp
>T212235 NZ_CP106999:714669-714965 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11035.67 Da Isoelectric Point: 5.1667
>AT212235 WP_007776551.1 NZ_CP080591:c2832305-2832006 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL
Download Length: 300 bp
>AT212235 NZ_CP106999:714967-715362 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|