Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2762655..2763300 Replicon chromosome
Accession NZ_CP080591
Organism Cronobacter sakazakii strain Crono-589

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag K1721_RS13095 Protein ID WP_004388208.1
Coordinates 2762938..2763300 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag K1721_RS13090 Protein ID WP_004388209.1
Coordinates 2762655..2762951 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1721_RS13080 (K1721_13065) 2760309..2761157 - 849 WP_032988319.1 DNA-3-methyladenine glycosylase 2 -
K1721_RS13085 (K1721_13070) 2761293..2762645 + 1353 WP_032988318.1 molecular chaperone -
K1721_RS13090 (K1721_13075) 2762655..2762951 - 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
K1721_RS13095 (K1721_13080) 2762938..2763300 - 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1721_RS13100 (K1721_13085) 2763531..2764778 + 1248 WP_032988317.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
K1721_RS13105 (K1721_13090) 2764778..2767900 + 3123 WP_032988316.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T212234 WP_004388208.1 NZ_CP080591:c2763300-2762938 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T212234 NZ_CP106999:648758-649072 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT212234 WP_004388209.1 NZ_CP080591:c2762951-2762655 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT212234 NZ_CP106999:649069-649485 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References