Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2098996..2099561 Replicon chromosome
Accession NZ_CP080591
Organism Cronobacter sakazakii strain Crono-589

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K1721_RS09855 Protein ID WP_032989567.1
Coordinates 2098996..2099274 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag K1721_RS09860 Protein ID WP_004388462.1
Coordinates 2099274..2099561 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1721_RS09840 (K1721_09845) 2094062..2095999 + 1938 WP_032989570.1 methyl-accepting chemotaxis protein -
K1721_RS09845 (K1721_09850) 2096107..2097093 + 987 WP_007888785.1 SDR family oxidoreductase -
K1721_RS09850 (K1721_09855) 2097095..2098699 - 1605 WP_032989568.1 alpha-amylase family protein -
K1721_RS09855 (K1721_09860) 2098996..2099274 + 279 WP_032989567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1721_RS09860 (K1721_09865) 2099274..2099561 + 288 WP_004388462.1 HigA family addiction module antitoxin Antitoxin
K1721_RS09865 (K1721_09870) 2099616..2101733 - 2118 WP_032989566.1 TonB-dependent receptor PqqU -
K1721_RS09870 (K1721_09875) 2102011..2103069 + 1059 WP_032989565.1 YncE family protein -
K1721_RS09875 (K1721_09880) 2103099..2103965 - 867 WP_032989564.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.11 Da        Isoelectric Point: 10.0888

>T212225 WP_032989567.1 NZ_CP080591:2098996-2099274 [Cronobacter sakazakii]
MIRSFRHKGLQRYFETGSTAGIHALHARKISLRLAVLNQAIRPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNYEDYH

Download         Length: 279 bp

>T212225 NZ_CP106998:3561455-3561673 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10428.03 Da        Isoelectric Point: 8.7791

>AT212225 WP_004388462.1 NZ_CP080591:2099274-2099561 [Cronobacter sakazakii]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFQA
RQSVDFSHLQRLQRA

Download         Length: 288 bp

>AT212225 NZ_CP106998:3561055-3561429 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References