Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 336512..337119 Replicon chromosome
Accession NZ_CP080590
Organism Devosia salina strain SCS-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K1X15_RS01645 Protein ID WP_220307390.1
Coordinates 336796..337119 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1X15_RS01640 Protein ID WP_220305770.1
Coordinates 336512..336799 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X15_RS01615 (K1X15_01615) 332114..333481 + 1368 WP_036744230.1 chromate efflux transporter -
K1X15_RS01620 (K1X15_01620) 333669..334361 - 693 WP_220305766.1 ArdC-like ssDNA-binding domain-containing protein -
K1X15_RS01625 (K1X15_01625) 334744..335202 + 459 WP_240549718.1 winged helix-turn-helix domain-containing protein -
K1X15_RS01630 (K1X15_01630) 335224..335760 - 537 WP_220305768.1 hypothetical protein -
K1X15_RS01635 (K1X15_01635) 335760..336515 - 756 WP_220305769.1 hypothetical protein -
K1X15_RS01640 (K1X15_01640) 336512..336799 - 288 WP_220305770.1 helix-turn-helix transcriptional regulator Antitoxin
K1X15_RS01645 (K1X15_01645) 336796..337119 - 324 WP_220307390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1X15_RS01650 (K1X15_01650) 337159..340350 - 3192 WP_220305771.1 Eco57I restriction-modification methylase domain-containing protein -
K1X15_RS01655 (K1X15_01655) 340361..340642 - 282 WP_220305772.1 hypothetical protein -
K1X15_RS01660 (K1X15_01660) 340744..342114 - 1371 WP_240549624.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 293801..342292 48491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12442.77 Da        Isoelectric Point: 11.3569

>T212221 WP_220307390.1 NZ_CP080590:c337119-336796 [Devosia salina]
ISWKIEILSDTVRAELEALPADQIARFLRIGELIQSLGLERVREPHVKHLEGPLWEIRMKGRDGISRALYVVARPKRVVV
VRIFVKKSQKTPRREIELALKRAKDVR

Download         Length: 324 bp

>T212221 NZ_CP106998:2300493-2301815 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10586.06 Da        Isoelectric Point: 8.4933

>AT212221 WP_220305770.1 NZ_CP080590:c336799-336512 [Devosia salina]
MTSLNELKKDLLKRADVRAEYESLAEEFSIAEALIRARSEADLTQTELAERMHTSQSYIAKLESGRVSPSMKALQRYAAA
TGSRLKISLERAVSP

Download         Length: 288 bp

>AT212221 NZ_CP106998:2300227-2300493 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References