Detailed information of TA system TA212189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2597462..2597646
• Replicon: chromosome
• Accession: NZ_CP080566
• Organism: Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: JMO16_RS13205
• Protein ID: WP_000482652.1
• Coordinates: 2597539..2597646 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2597462..2597522 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO16_RS13190	2592917..2593048	-	132	WP_223197975.1	hypothetical protein	-
JMO16_RS13195	2593315..2595048	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
JMO16_RS13200	2595073..2596836	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2597462..2597522	+	61	-	-	Antitoxin
JMO16_RS13205	2597539..2597646	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO16_RS13210	2597780..2598166	-	387	WP_000779360.1	flippase GtxA	-
JMO16_RS13215	2598434..2599576	+	1143	WP_001176863.1	glycerate kinase	-
JMO16_RS13220	2599636..2600295	+	660	WP_000831298.1	membrane protein	-
JMO16_RS13225	2600477..2601688	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JMO16_RS13230	2601811..2602284	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212189 WP_000482652.1 NZ_CP080566:c2597646-2597539 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212189 NZ_CP106997:977325-977660 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT212189 NZ_CP080566:2597462-2597522 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin