Detailed information of TA system TA212185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2305976..2306192
• Replicon: chromosome
• Accession: NZ_CP080566
• Organism: Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JMO16_RS11675
• Protein ID: WP_001802298.1
• Coordinates: 2306088..2306192 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2305976..2306031 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO16_RS11655	2302182..2302847	-	666	WP_001024095.1	SDR family oxidoreductase	-
JMO16_RS11660	2302999..2303319	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JMO16_RS11665	2303321..2304298	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
JMO16_RS11670	2304564..2305655	+	1092	WP_000495669.1	hypothetical protein	-
-	2305976..2306031	+	56	-	-	Antitoxin
JMO16_RS11675	2306088..2306192	-	105	WP_001802298.1	hypothetical protein	Toxin
JMO16_RS11680	2306709..2306879	+	171	WP_001792292.1	transposase	-
JMO16_RS11685	2306872..2307030	+	159	WP_001792784.1	hypothetical protein	-
JMO16_RS11690	2307688..2308545	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
JMO16_RS11695	2308613..2309395	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212185 WP_001802298.1 NZ_CP080566:c2306192-2306088 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212185 NZ_CP106997:c605876-605412 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212185 NZ_CP080566:2305976-2306031 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin