Detailed information of TA system TA212176

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1953933..1954113
• Replicon: chromosome
• Accession: NZ_CP080566
• Organism: Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO16_RS09590
• Protein ID: WP_001801861.1
• Coordinates: 1953933..1954028 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1954056..1954113 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO16_RS09560	1949096..1949746	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
JMO16_RS09565	1949827..1950822	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
JMO16_RS09570	1950897..1951523	+	627	WP_000669024.1	hypothetical protein	-
JMO16_RS09575	1951564..1951905	+	342	WP_000627540.1	DUF3969 family protein	-
JMO16_RS09580	1952006..1952578	+	573	WP_000414216.1	hypothetical protein	-
JMO16_RS09585	1952776..1953788	-	1013	Protein_1903	IS3 family transposase	-
JMO16_RS09590	1953933..1954028	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1954056..1954113	-	58	-	-	Antitoxin
JMO16_RS09595	1954151..1954252	+	102	WP_001792025.1	hypothetical protein	-
JMO16_RS09600	1954230..1954391	-	162	Protein_1906	transposase	-
JMO16_RS09605	1954376..1954786	-	411	WP_001808705.1	IS21 family transposase	-
JMO16_RS09610	1955328..1956557	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
JMO16_RS09615	1956550..1958106	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
JMO16_RS09620	1958270..1958404	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1929915..1980945	51030

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212176 WP_001801861.1 NZ_CP080566:1953933-1954028 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212176 NZ_CP106996:2671044-2671151 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT212176 NZ_CP080566:c1954113-1954056 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin