Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1606266..1606680 | Replicon | chromosome |
| Accession | NZ_CP080566 | ||
| Organism | Staphylococcus aureus strain HL20835 isolate HL20835 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | JMO16_RS07805 | Protein ID | WP_031267622.1 |
| Coordinates | 1606429..1606680 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JMO16_RS07800 | Protein ID | WP_000028424.1 |
| Coordinates | 1606266..1606439 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO16_RS07760 (1601530) | 1601530..1601820 | - | 291 | WP_000665205.1 | VRR-NUC domain-containing protein | - |
| JMO16_RS07765 (1601954) | 1601954..1602052 | + | 99 | WP_001801650.1 | hypothetical protein | - |
| JMO16_RS07770 (1602161) | 1602161..1604608 | - | 2448 | WP_000884870.1 | VapE family protein | - |
| JMO16_RS07775 (1604896) | 1604896..1605096 | - | 201 | WP_000265252.1 | DUF1514 family protein | - |
| JMO16_RS07780 (1605164) | 1605164..1605316 | - | 153 | WP_000595263.1 | transcriptional activator RinB | - |
| JMO16_RS07785 (1605313) | 1605313..1605519 | - | 207 | WP_000195810.1 | DUF1381 domain-containing protein | - |
| JMO16_RS07790 (1605556) | 1605556..1606089 | - | 534 | WP_063653166.1 | dUTPase | - |
| JMO16_RS07795 (1606104) | 1606104..1606265 | - | 162 | WP_000889684.1 | hypothetical protein | - |
| JMO16_RS07800 (1606266) | 1606266..1606439 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| JMO16_RS07805 (1606429) | 1606429..1606680 | - | 252 | WP_031267622.1 | DUF1024 family protein | Toxin |
| JMO16_RS07810 (1606673) | 1606673..1606980 | - | 308 | Protein_1548 | hypothetical protein | - |
| JMO16_RS07815 (1606977) | 1606977..1607324 | - | 348 | WP_000979209.1 | YopX family protein | - |
| JMO16_RS07820 (1607321) | 1607321..1607701 | - | 381 | WP_001668982.1 | hypothetical protein | - |
| JMO16_RS07825 (1607704) | 1607704..1607910 | - | 207 | WP_000693989.1 | hypothetical protein | - |
| JMO16_RS07830 (1607924) | 1607924..1608172 | - | 249 | WP_060474161.1 | SAV1978 family virulence-associated passenger protein | - |
| JMO16_RS07835 (1608172) | 1608172..1608426 | - | 255 | WP_000022722.1 | DUF3310 domain-containing protein | - |
| JMO16_RS07840 (1608423) | 1608423..1608827 | - | 405 | WP_044426014.1 | SA1788 family PVL leukocidin-associated protein | - |
| JMO16_RS07845 (1608827) | 1608827..1609012 | - | 186 | WP_001164629.1 | DUF3113 family protein | - |
| JMO16_RS07850 (1609025) | 1609025..1610977 | - | 1953 | WP_078064460.1 | DNA polymerase | - |
| JMO16_RS07855 (1611045) | 1611045..1611602 | - | 558 | WP_000645045.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1574610..1637566 | 62956 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9419.35 Da Isoelectric Point: 3.9476
>T212172 WP_031267622.1 NZ_CP080566:c1606680-1606429 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T212172 NZ_CP106996:2247036-2247323 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT212172 WP_000028424.1 NZ_CP080566:c1606439-1606266 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT212172 NZ_CP106996:2246797-2247036 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|