Detailed information of TA system TA212168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2472620..2473143
• Replicon: chromosome
• Accession: NZ_CP080564
• Organism: Staphylococcus aureus strain HL16278

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: JMO07_RS12195
• Protein ID: WP_000074043.1
• Coordinates: 2472620..2472886 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: JMO07_RS12200
• Protein ID: WP_000587618.1
• Coordinates: 2472886..2473143 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO07_RS12175 (2467926)	2467926..2469113	-	1188	WP_000026187.1	MFS transporter	-
JMO07_RS12180 (2469509)	2469509..2470285	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
JMO07_RS12185 (2470278)	2470278..2470940	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
JMO07_RS12190 (2471188)	2471188..2472264	-	1077	WP_001076665.1	M42 family metallopeptidase	-
JMO07_RS12195 (2472620)	2472620..2472886	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
JMO07_RS12200 (2472886)	2472886..2473143	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMO07_RS12205 (2473503)	2473503..2473958	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
JMO07_RS12210 (2474126)	2474126..2475703	-	1578	WP_220332262.1	FMN-binding glutamate synthase family protein	-
JMO07_RS12215 (2475899)	2475899..2476648	+	750	WP_000072441.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T212168 WP_000074043.1 NZ_CP080564:c2472886-2472620 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T212168 NZ_CP106996:1800235-1800486 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT212168 WP_000587618.1 NZ_CP080564:c2473143-2472886 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT212168 NZ_CP106996:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2