Detailed information of TA system TA212166

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2441439..2441623
• Replicon: chromosome
• Accession: NZ_CP080564
• Organism: Staphylococcus aureus strain HL16278

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: JMO07_RS12055
• Protein ID: WP_000482650.1
• Coordinates: 2441516..2441623 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2441439..2441499 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO07_RS12040	2436949..2437116	-	168	WP_001792506.1	hypothetical protein	-
JMO07_RS12045	2437347..2439080	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
JMO07_RS12050	2439105..2440868	-	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
-	2441439..2441499	+	61	-	-	Antitoxin
JMO07_RS12055	2441516..2441623	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO07_RS12060	2441757..2442143	-	387	WP_000779358.1	flippase GtxA	-
JMO07_RS12065	2442401..2443543	+	1143	WP_001176863.1	glycerate kinase	-
JMO07_RS12070	2443603..2444262	+	660	WP_000831298.1	membrane protein	-
JMO07_RS12075	2444444..2445655	+	1212	WP_220332261.1	multidrug effflux MFS transporter	-
JMO07_RS12080	2445778..2446251	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212166 WP_000482650.1 NZ_CP080564:c2441623-2441516 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212166 NZ_CP106996:c1111740-1111411 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT212166 NZ_CP080564:2441439-2441499 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin