Detailed information of TA system TA212158

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1987069..1987376
• Replicon: chromosome
• Accession: NZ_CP080564
• Organism: Staphylococcus aureus strain HL16278

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JMO07_RS09635
• Protein ID: WP_011447039.1
• Coordinates: 1987200..1987376 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1987069..1987208 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO07_RS13620 (1982643)	1982643..1982708	+	66	Protein_1865	hypothetical protein	-
JMO07_RS09600 (1982732)	1982732..1983072	-	341	Protein_1866	complement inhibitor SCIN-A	-
JMO07_RS09605 (1983756)	1983756..1984205	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
JMO07_RS09610 (1984300)	1984300..1984635	-	336	Protein_1868	SH3 domain-containing protein	-
JMO07_RS09615 (1985285)	1985285..1985776	-	492	WP_000919350.1	staphylokinase	-
JMO07_RS09620 (1985967)	1985967..1986722	-	756	WP_000861038.1	CHAP domain-containing protein	-
JMO07_RS09625 (1986734)	1986734..1986988	-	255	WP_000611512.1	phage holin	-
JMO07_RS09630 (1987040)	1987040..1987147	+	108	WP_001791821.1	hypothetical protein	-
- (1987069)	1987069..1987208	+	140	NuclAT_0	-	Antitoxin
- (1987069)	1987069..1987208	+	140	NuclAT_0	-	Antitoxin
- (1987069)	1987069..1987208	+	140	NuclAT_0	-	Antitoxin
- (1987069)	1987069..1987208	+	140	NuclAT_0	-	Antitoxin
JMO07_RS09635 (1987200)	1987200..1987376	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
JMO07_RS09640 (1987526)	1987526..1987822	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
JMO07_RS09645 (1987880)	1987880..1988167	-	288	WP_001040261.1	hypothetical protein	-
JMO07_RS09650 (1988214)	1988214..1988366	-	153	WP_001153681.1	hypothetical protein	-
JMO07_RS09655 (1988356)	1988356..1992141	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / scn / chp / sak / hlb / groEL	1977401..2034900	57499
	-	flank	IS/Tn	-	-	1981305..1982624	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212158 WP_011447039.1 NZ_CP080564:c1987376-1987200 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212158 NZ_CP106995:c4119378-4119028 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT212158 NZ_CP080564:1987069-1987208 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin