Detailed information of TA system TA212155

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1821242..1821428
• Replicon: chromosome
• Accession: NZ_CP080564
• Organism: Staphylococcus aureus strain HL16278

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JMO07_RS08610
• Protein ID: WP_001801861.1
• Coordinates: 1821242..1821337 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1821365..1821428 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO07_RS08575	1816283..1816909	+	627	WP_000669021.1	hypothetical protein	-
JMO07_RS08580	1816950..1817291	+	342	WP_000627547.1	DUF3969 family protein	-
JMO07_RS08585	1817392..1817964	+	573	WP_000414206.1	hypothetical protein	-
JMO07_RS08590	1818162..1818790	-	629	Protein_1699	ImmA/IrrE family metallo-endopeptidase	-
JMO07_RS08595	1819090..1819266	-	177	WP_000375476.1	hypothetical protein	-
JMO07_RS08600	1819277..1819660	-	384	WP_000070811.1	hypothetical protein	-
JMO07_RS08605	1820345..1820791	-	447	WP_000747802.1	DUF1433 domain-containing protein	-
JMO07_RS08610	1821242..1821337	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1821365..1821428	-	64	-	-	Antitoxin
JMO07_RS08615	1821466..1821567	+	102	WP_001791232.1	hypothetical protein	-
JMO07_RS08620	1821545..1821727	-	183	Protein_1705	transposase	-
JMO07_RS08625	1821915..1822289	-	375	WP_000695818.1	DUF1433 domain-containing protein	-
JMO07_RS08630	1822311..1822589	-	279	WP_001798632.1	DUF1433 domain-containing protein	-
JMO07_RS08635	1822895..1823311	-	417	WP_020978241.1	DUF1433 domain-containing protein	-
JMO07_RS08640	1823958..1825076	-	1119	WP_000072558.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1813725..1870048	56323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212155 WP_001801861.1 NZ_CP080564:1821242-1821337 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212155 NZ_CP106995:c3753913-3753515 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT212155 NZ_CP080564:c1821428-1821365 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATAAAAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin