Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2630307..2630491 Replicon chromosome
Accession NZ_CP080562
Organism Staphylococcus aureus strain HL21008

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag JMO08_RS13330 Protein ID WP_000482652.1
Coordinates 2630384..2630491 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2630307..2630367 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO08_RS13315 (JMO08_002663) 2625762..2625893 - 132 WP_223197975.1 hypothetical protein -
JMO08_RS13320 (JMO08_002664) 2626160..2627893 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
JMO08_RS13325 (JMO08_002665) 2627918..2629681 - 1764 WP_220353766.1 ABC transporter ATP-binding protein -
- 2630307..2630367 + 61 - - Antitoxin
JMO08_RS13330 (JMO08_002666) 2630384..2630491 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
JMO08_RS13335 (JMO08_002667) 2630625..2631011 - 387 WP_000779360.1 flippase GtxA -
JMO08_RS13340 (JMO08_002668) 2631279..2632421 + 1143 WP_001176863.1 glycerate kinase -
JMO08_RS13345 (JMO08_002669) 2632481..2633140 + 660 WP_000831298.1 membrane protein -
JMO08_RS13350 (JMO08_002670) 2633322..2634533 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
JMO08_RS13355 (JMO08_002671) 2634656..2635129 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T212151 WP_000482652.1 NZ_CP080562:c2630491-2630384 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T212151 NZ_CP106995:2670509-2670616 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT212151 NZ_CP080562:2630307-2630367 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References