Detailed information of TA system TA212150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2604812..2605329
• Replicon: chromosome
• Accession: NZ_CP080562
• Organism: Staphylococcus aureus strain HL21008

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: JMO08_RS13195
• Protein ID: WP_000113265.1
• Coordinates: 2604812..2605078 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: JMO08_RS13200
• Protein ID: WP_000584499.1
• Coordinates: 2605078..2605329 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO08_RS13165 (JMO08_002633)	2600240..2600776	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
JMO08_RS13170 (JMO08_002634)	2601010..2601834	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
JMO08_RS13175 (JMO08_002635)	2602051..2602233	-	183	WP_000230292.1	hypothetical protein	-
JMO08_RS13180 (JMO08_002636)	2602317..2602784	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
JMO08_RS13185 (JMO08_002637)	2602970..2604517	-	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
JMO08_RS13190 (JMO08_002638)	2604706..2604777	-	72	Protein_2568	hypothetical protein	-
JMO08_RS13195 (JMO08_002639)	2604812..2605078	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
JMO08_RS13200 (JMO08_002640)	2605078..2605329	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMO08_RS13205 (JMO08_002641)	2605494..2605574	-	81	WP_223197974.1	hypothetical protein	-
JMO08_RS13210 (JMO08_002642)	2605602..2606201	-	600	WP_000162810.1	DsbA family protein	-
JMO08_RS13215 (JMO08_002643)	2606220..2606582	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
JMO08_RS13220 (JMO08_002644)	2606837..2608087	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
JMO08_RS13225 (JMO08_002645)	2608184..2608915	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
JMO08_RS13230 (JMO08_002646)	2608912..2609631	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T212150 WP_000113265.1 NZ_CP080562:c2605078-2604812 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T212150 NZ_CP106995:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT212150 WP_000584499.1 NZ_CP080562:c2605329-2605078 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT212150 NZ_CP106995:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60