Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2604812..2605329 | Replicon | chromosome |
| Accession | NZ_CP080562 | ||
| Organism | Staphylococcus aureus strain HL21008 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | JMO08_RS13195 | Protein ID | WP_000113265.1 |
| Coordinates | 2604812..2605078 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | JMO08_RS13200 | Protein ID | WP_000584499.1 |
| Coordinates | 2605078..2605329 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO08_RS13165 (JMO08_002633) | 2600240..2600776 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| JMO08_RS13170 (JMO08_002634) | 2601010..2601834 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| JMO08_RS13175 (JMO08_002635) | 2602051..2602233 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| JMO08_RS13180 (JMO08_002636) | 2602317..2602784 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| JMO08_RS13185 (JMO08_002637) | 2602970..2604517 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| JMO08_RS13190 (JMO08_002638) | 2604706..2604777 | - | 72 | Protein_2568 | hypothetical protein | - |
| JMO08_RS13195 (JMO08_002639) | 2604812..2605078 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| JMO08_RS13200 (JMO08_002640) | 2605078..2605329 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JMO08_RS13205 (JMO08_002641) | 2605494..2605574 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| JMO08_RS13210 (JMO08_002642) | 2605602..2606201 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| JMO08_RS13215 (JMO08_002643) | 2606220..2606582 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| JMO08_RS13220 (JMO08_002644) | 2606837..2608087 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| JMO08_RS13225 (JMO08_002645) | 2608184..2608915 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| JMO08_RS13230 (JMO08_002646) | 2608912..2609631 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T212150 WP_000113265.1 NZ_CP080562:c2605078-2604812 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T212150 NZ_CP106995:c2382413-2382237 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT212150 WP_000584499.1 NZ_CP080562:c2605329-2605078 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT212150 NZ_CP106995:c2382191-2381775 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|