Detailed information of TA system TA212145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2300938..2301216
• Replicon: chromosome
• Accession: NZ_CP080562
• Organism: Staphylococcus aureus strain HL21008

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JMO08_RS11540
• Protein ID: WP_001802298.1
• Coordinates: 2301112..2301216 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2300938..2301116 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO08_RS11520 (JMO08_002304)	2297206..2297871	-	666	WP_001024095.1	SDR family oxidoreductase	-
JMO08_RS11525 (JMO08_002305)	2298023..2298343	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JMO08_RS11530 (JMO08_002306)	2298345..2299322	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
JMO08_RS11535 (JMO08_002307)	2299588..2300679	+	1092	WP_000495669.1	hypothetical protein	-
-	2300938..2301116	+	179	-	-	Antitoxin
JMO08_RS11540 (JMO08_002308)	2301112..2301216	-	105	WP_001802298.1	hypothetical protein	Toxin
JMO08_RS11545 (JMO08_002309)	2301896..2302054	+	159	WP_001792784.1	hypothetical protein	-
JMO08_RS11550 (JMO08_002310)	2302712..2303569	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
JMO08_RS11555 (JMO08_002311)	2303637..2304419	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212145 WP_001802298.1 NZ_CP080562:c2301216-2301112 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212145 NZ_CP106995:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT212145 NZ_CP080562:2300938-2301116 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin