Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2002311..2002491 Replicon chromosome
Accession NZ_CP080562
Organism Staphylococcus aureus strain HL21008

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag JMO08_RS09835 Protein ID WP_001801861.1
Coordinates 2002311..2002406 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2002434..2002491 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO08_RS09805 (JMO08_001961) 1997474..1998124 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
JMO08_RS09810 (JMO08_001962) 1998205..1999200 + 996 WP_000070642.1 DUF4352 domain-containing protein -
JMO08_RS09815 (JMO08_001963) 1999275..1999901 + 627 WP_000669024.1 hypothetical protein -
JMO08_RS09820 (JMO08_001964) 1999942..2000283 + 342 WP_000627540.1 DUF3969 family protein -
JMO08_RS09825 (JMO08_001965) 2000384..2000956 + 573 WP_000414216.1 hypothetical protein -
JMO08_RS09830 (JMO08_001966) 2001154..2002166 - 1013 Protein_1946 IS3 family transposase -
JMO08_RS09835 (JMO08_001967) 2002311..2002406 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2002434..2002491 - 58 - - Antitoxin
JMO08_RS09840 (JMO08_001968) 2002529..2002630 + 102 WP_001792025.1 hypothetical protein -
JMO08_RS09845 (JMO08_001969) 2002608..2002769 - 162 Protein_1949 transposase -
JMO08_RS09850 (JMO08_001970) 2002754..2003164 - 411 WP_001808705.1 IS21 family transposase -
JMO08_RS09855 (JMO08_001971) 2003706..2004936 - 1231 Protein_1951 restriction endonuclease subunit S -
JMO08_RS09860 (JMO08_001972) 2004929..2006485 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
JMO08_RS09865 (JMO08_001973) 2006649..2006783 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 1978293..2077037 98744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T212139 WP_001801861.1 NZ_CP080562:2002311-2002406 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T212139 NZ_CP106995:714669-714965 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT212139 NZ_CP080562:c2002491-2002434 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References