Detailed information of TA system TA212136

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1667935..1668514
• Replicon: chromosome
• Accession: NZ_CP080562
• Organism: Staphylococcus aureus strain HL21008

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JMO08_RS08175
• Protein ID: WP_001025401.1
• Coordinates: 1668269..1668514 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1667935..1668300 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO08_RS08135 (JMO08_001627)	1664679..1665236	-	558	WP_000645045.1	DUF2815 family protein	-
JMO08_RS08140 (JMO08_001628)	1665262..1666428	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
JMO08_RS08145 (JMO08_001629)	1666425..1666787	-	363	WP_000279445.1	hypothetical protein	-
JMO08_RS08150 (JMO08_001630)	1666802..1667125	-	324	WP_000174995.1	hypothetical protein	-
JMO08_RS08155 (JMO08_001631)	1667204..1667365	-	162	WP_015986189.1	DUF1270 family protein	-
JMO08_RS08160 (JMO08_001632)	1667377..1667640	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
JMO08_RS08165 (JMO08_001633)	1667665..1667880	-	216	WP_001097552.1	hypothetical protein	-
JMO08_RS08170 (JMO08_001634)	1667935..1668300	+	366	WP_001128433.1	hypothetical protein	Antitoxin
JMO08_RS08175 (JMO08_001635)	1668269..1668514	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JMO08_RS08180 (JMO08_001636)	1668570..1668779	+	210	WP_000642492.1	hypothetical protein	-
JMO08_RS08185 (JMO08_001637)	1668769..1668912	-	144	WP_000939498.1	hypothetical protein	-
JMO08_RS08190 (JMO08_001638)	1668927..1669370	-	444	WP_044414793.1	hypothetical protein	-
JMO08_RS08195 (JMO08_001639)	1669394..1669615	-	222	WP_031887876.1	DUF739 family protein	-
JMO08_RS08200 (JMO08_001640)	1669776..1670546	+	771	WP_031887877.1	S24 family peptidase	-
JMO08_RS08205 (JMO08_001641)	1670558..1670704	+	147	WP_001049401.1	hypothetical protein	-
JMO08_RS08210 (JMO08_001642)	1670701..1670886	+	186	WP_000109189.1	hypothetical protein	-
JMO08_RS08215 (JMO08_001643)	1670956..1671123	+	168	WP_000705241.1	hypothetical protein	-
JMO08_RS08220 (JMO08_001644)	1671263..1671967	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JMO08_RS08225 (JMO08_001645)	1672178..1673383	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp / gnd	1612243..1697745	85502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T212136 WP_001025401.1 NZ_CP080562:c1668514-1668269 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T212136 NZ_CP106995:183125-183232 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT212136 NZ_CP080562:1667935-1668300 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin