Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2613841..2614025 Replicon chromosome
Accession NZ_CP080560
Organism Staphylococcus aureus strain HL17064

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag JMO09_RS13200 Protein ID WP_000482652.1
Coordinates 2613918..2614025 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2613841..2613901 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO09_RS13185 (JMO09_002637) 2609296..2609427 - 132 WP_223197975.1 hypothetical protein -
JMO09_RS13190 (JMO09_002638) 2609694..2611427 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
JMO09_RS13195 (JMO09_002639) 2611452..2613215 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2613841..2613901 + 61 - - Antitoxin
JMO09_RS13200 (JMO09_002640) 2613918..2614025 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
JMO09_RS13205 (JMO09_002641) 2614159..2614545 - 387 WP_000779360.1 flippase GtxA -
JMO09_RS13210 (JMO09_002642) 2614813..2615955 + 1143 WP_001176863.1 glycerate kinase -
JMO09_RS13215 (JMO09_002643) 2616015..2616674 + 660 WP_000831298.1 membrane protein -
JMO09_RS13220 (JMO09_002644) 2616856..2618067 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
JMO09_RS13225 (JMO09_002645) 2618190..2618663 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T212132 WP_000482652.1 NZ_CP080560:c2614025-2613918 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T212132 NZ_CP106994:3759975-3760253 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 61 bp

>AT212132 NZ_CP080560:2613841-2613901 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References