Detailed information of TA system TA212130

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2328732..2328994
• Replicon: chromosome
• Accession: NZ_CP080560
• Organism: Staphylococcus aureus strain HL17064

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JMO09_RS11720
• Protein ID: WP_001802298.1
• Coordinates: 2328890..2328994 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2328732..2328895 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO09_RS11700 (JMO09_002340)	2324984..2325649	-	666	WP_001024095.1	SDR family oxidoreductase	-
JMO09_RS11705 (JMO09_002341)	2325801..2326121	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JMO09_RS11710 (JMO09_002342)	2326123..2327100	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
JMO09_RS11715 (JMO09_002343)	2327366..2328457	+	1092	WP_000495669.1	hypothetical protein	-
-	2328732..2328895	+	164	-	-	Antitoxin
JMO09_RS11720 (JMO09_002344)	2328890..2328994	-	105	WP_001802298.1	hypothetical protein	Toxin
JMO09_RS11725 (JMO09_002345)	2329674..2329832	+	159	WP_001792784.1	hypothetical protein	-
JMO09_RS11730 (JMO09_002346)	2330490..2331347	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
JMO09_RS11735 (JMO09_002347)	2331415..2332197	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212130 WP_001802298.1 NZ_CP080560:c2328994-2328890 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212130 NZ_CP106994:3743321-3743662 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT212130 NZ_CP080560:2328732-2328895 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin