Detailed information of TA system TA212123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1564646..1565225
• Replicon: chromosome
• Accession: NZ_CP080560
• Organism: Staphylococcus aureus strain HL17064

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JMO09_RS07815
• Protein ID: WP_001025401.1
• Coordinates: 1564646..1564891 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1564860..1565225 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO09_RS07765 (JMO09_001553)	1559777..1560982	-	1206	WP_031766111.1	site-specific integrase	-
JMO09_RS07770 (JMO09_001554)	1561193..1561897	-	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JMO09_RS07775 (JMO09_001555)	1562037..1562204	-	168	WP_000705241.1	hypothetical protein	-
JMO09_RS07780 (JMO09_001556)	1562274..1562459	-	186	WP_000109189.1	hypothetical protein	-
JMO09_RS07785 (JMO09_001557)	1562456..1562602	-	147	WP_001049401.1	hypothetical protein	-
JMO09_RS07790 (JMO09_001558)	1562614..1563384	-	771	WP_031887877.1	S24 family peptidase	-
JMO09_RS07795 (JMO09_001559)	1563545..1563766	+	222	WP_031887876.1	DUF739 family protein	-
JMO09_RS07800 (JMO09_001560)	1563790..1564233	+	444	WP_044414793.1	hypothetical protein	-
JMO09_RS07805 (JMO09_001561)	1564248..1564391	+	144	WP_000939498.1	hypothetical protein	-
JMO09_RS07810 (JMO09_001562)	1564381..1564590	-	210	WP_000642492.1	hypothetical protein	-
JMO09_RS07815 (JMO09_001563)	1564646..1564891	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JMO09_RS07820 (JMO09_001564)	1564860..1565225	-	366	WP_001128433.1	hypothetical protein	Antitoxin
JMO09_RS07825 (JMO09_001565)	1565280..1565495	+	216	WP_001097552.1	hypothetical protein	-
JMO09_RS07830 (JMO09_001566)	1565520..1565783	+	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
JMO09_RS07835 (JMO09_001567)	1565795..1565956	+	162	WP_015986189.1	DUF1270 family protein	-
JMO09_RS07840 (JMO09_001568)	1566035..1566358	+	324	WP_000174995.1	hypothetical protein	-
JMO09_RS07845 (JMO09_001569)	1566373..1566735	+	363	WP_000279445.1	hypothetical protein	-
JMO09_RS07850 (JMO09_001570)	1566732..1567898	+	1167	WP_220374328.1	DUF2800 domain-containing protein	-
JMO09_RS07855 (JMO09_001571)	1567924..1568481	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T212123 WP_001025401.1 NZ_CP080560:1564646-1564891 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T212123 NZ_CP106994:1967178-1967281 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 366 bp

>AT212123 NZ_CP080560:c1565225-1564860 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin