Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1230669..1230849 | Replicon | chromosome |
| Accession | NZ_CP080560 | ||
| Organism | Staphylococcus aureus strain HL17064 | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | JMO09_RS06155 | Protein ID | WP_001801861.1 |
| Coordinates | 1230754..1230849 (-) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1230669..1230726 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO09_RS06125 (JMO09_001225) | 1226378..1226512 | + | 135 | WP_001791797.1 | hypothetical protein | - |
| JMO09_RS06130 (JMO09_001226) | 1226676..1228232 | + | 1557 | WP_000028669.1 | type I restriction-modification system subunit M | - |
| JMO09_RS06135 (JMO09_001227) | 1228225..1229454 | + | 1230 | WP_000072626.1 | restriction endonuclease subunit S | - |
| JMO09_RS06140 (JMO09_001228) | 1229996..1230406 | + | 411 | WP_001808705.1 | IS21 family transposase | - |
| JMO09_RS06145 (JMO09_001229) | 1230391..1230552 | + | 162 | Protein_1209 | transposase | - |
| JMO09_RS06150 (JMO09_001230) | 1230530..1230631 | - | 102 | WP_001792025.1 | hypothetical protein | - |
| - | 1230669..1230726 | + | 58 | - | - | Antitoxin |
| JMO09_RS06155 (JMO09_001231) | 1230754..1230849 | - | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| JMO09_RS06160 (JMO09_001232) | 1230994..1232006 | + | 1013 | Protein_1212 | IS3 family transposase | - |
| JMO09_RS06165 (JMO09_001233) | 1232204..1232776 | - | 573 | WP_000414216.1 | hypothetical protein | - |
| JMO09_RS06170 (JMO09_001234) | 1232877..1233218 | - | 342 | WP_000627540.1 | DUF3969 family protein | - |
| JMO09_RS06175 (JMO09_001235) | 1233259..1233885 | - | 627 | WP_000669024.1 | hypothetical protein | - |
| JMO09_RS06180 (JMO09_001236) | 1233960..1234955 | - | 996 | WP_000070642.1 | DUF4352 domain-containing protein | - |
| JMO09_RS06185 (JMO09_001237) | 1235036..1235686 | - | 651 | WP_001795210.1 | excalibur calcium-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / hlgA / lukD | 1156678..1236444 | 79766 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T212121 WP_001801861.1 NZ_CP080560:c1230849-1230754 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T212121 NZ_CP106994:1800483-1800737 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 58 bp
>AT212121 NZ_CP080560:1230669-1230726 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
