Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2579734..2580251 | Replicon | chromosome |
| Accession | NZ_CP080556 | ||
| Organism | Staphylococcus aureus strain HL17078 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | JMO10_RS13095 | Protein ID | WP_000113262.1 |
| Coordinates | 2579734..2580000 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A5A8VWS3 |
| Locus tag | JMO10_RS13100 | Protein ID | WP_000584502.1 |
| Coordinates | 2580000..2580251 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO10_RS13065 (2575160) | 2575160..2575696 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| JMO10_RS13070 (2575929) | 2575929..2576753 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| JMO10_RS13075 (2576970) | 2576970..2577152 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| JMO10_RS13080 (2577236) | 2577236..2577703 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| JMO10_RS13085 (2577889) | 2577889..2579439 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| JMO10_RS13090 (2579628) | 2579628..2579699 | - | 72 | Protein_2542 | hypothetical protein | - |
| JMO10_RS13095 (2579734) | 2579734..2580000 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| JMO10_RS13100 (2580000) | 2580000..2580251 | - | 252 | WP_000584502.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JMO10_RS13105 (2580416) | 2580416..2580517 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| JMO10_RS13110 (2580524) | 2580524..2581123 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| JMO10_RS13115 (2581142) | 2581142..2581501 | - | 360 | WP_000819847.1 | DUF4467 domain-containing protein | - |
| JMO10_RS13120 (2581756) | 2581756..2583006 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| JMO10_RS13125 (2583103) | 2583103..2583834 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| JMO10_RS13130 (2583831) | 2583831..2584550 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T212116 WP_000113262.1 NZ_CP080556:c2580000-2579734 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T212116 NZ_CP106994:846265-846672 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9417.65 Da Isoelectric Point: 4.4702
>AT212116 WP_000584502.1 NZ_CP080556:c2580251-2580000 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT212116 NZ_CP106994:846018-846284 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6L8G | |
| PDB | 6L8F | |
| PDB | 7CUA | |
| PDB | 6L8E |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5A8VWS3 |