Detailed information of TA system TA212113

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2313520..2313799
• Replicon: chromosome
• Accession: NZ_CP080556
• Organism: Staphylococcus aureus strain HL17078

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JMO10_RS11700
• Protein ID: WP_001802298.1
• Coordinates: 2313695..2313799 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2313520..2313699 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO10_RS11680	2309719..2310384	-	666	WP_001024094.1	SDR family oxidoreductase	-
JMO10_RS11685	2310536..2310856	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JMO10_RS11690	2310858..2311838	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
JMO10_RS11695	2312104..2313195	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2313520..2313699	+	180	-	-	Antitoxin
JMO10_RS11700	2313695..2313799	-	105	WP_001802298.1	hypothetical protein	Toxin
JMO10_RS11705	2313960..2314443	-	484	Protein_2274	recombinase family protein	-
JMO10_RS11710	2314486..2315622	-	1137	WP_000115564.1	SAP domain-containing protein	-
JMO10_RS11715	2315911..2316003	+	93	WP_001790138.1	hypothetical protein	-
JMO10_RS15210	2316292..2316476	+	185	Protein_2277	exotoxin	-
JMO10_RS11720	2316708..2317565	-	858	WP_000370924.1	HAD family hydrolase	-
JMO10_RS11725	2317633..2318415	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212113 WP_001802298.1 NZ_CP080556:c2313799-2313695 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212113 NZ_CP106994:c605876-605412 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT212113 NZ_CP080556:2313520-2313699 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin