Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2631567..2632090 Replicon chromosome
Accession NZ_CP080553
Organism Staphylococcus aureus strain HL18380

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag JMO11_RS13350 Protein ID WP_000074048.1
Coordinates 2631567..2631833 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JMO11_RS13355 Protein ID WP_000587616.1
Coordinates 2631833..2632090 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO11_RS13330 (2626874) 2626874..2628061 - 1188 WP_000026194.1 MFS transporter -
JMO11_RS13335 (2628457) 2628457..2629233 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
JMO11_RS13340 (2629226) 2629226..2629888 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
JMO11_RS13345 (2630136) 2630136..2631212 - 1077 WP_001076671.1 M42 family metallopeptidase -
JMO11_RS13350 (2631567) 2631567..2631833 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
JMO11_RS13355 (2631833) 2631833..2632090 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO11_RS13360 (2632196) 2632196..2632390 - 195 WP_001790145.1 hypothetical protein -
JMO11_RS13365 (2632449) 2632449..2632904 + 456 WP_000732082.1 DUF1307 domain-containing protein -
JMO11_RS13370 (2633072) 2633072..2634649 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
JMO11_RS13375 (2634844) 2634844..2635593 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
JMO11_RS13380 (2635817) 2635817..2637010 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T212102 WP_000074048.1 NZ_CP080553:c2631833-2631567 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T212102 NZ_CP106964:c5439750-5439367 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT212102 WP_000587616.1 NZ_CP080553:c2632090-2631833 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT212102 NZ_CP106964:c5439992-5439750 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References