Detailed information of TA system TA212100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2600067..2600251
• Replicon: chromosome
• Accession: NZ_CP080553
• Organism: Staphylococcus aureus strain HL18380

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: JMO11_RS13210
• Protein ID: WP_000482650.1
• Coordinates: 2600144..2600251 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2600067..2600127 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO11_RS13195	2595597..2595764	-	168	WP_001790576.1	hypothetical protein	-
JMO11_RS13200	2595995..2597728	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
JMO11_RS13205	2597753..2599516	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2600067..2600127	+	61	-	-	Antitoxin
JMO11_RS13210	2600144..2600251	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
JMO11_RS13215	2600385..2600771	-	387	WP_000779358.1	flippase GtxA	-
JMO11_RS13220	2601039..2602181	+	1143	WP_001176863.1	glycerate kinase	-
JMO11_RS13225	2602241..2602900	+	660	WP_000831298.1	membrane protein	-
JMO11_RS13230	2603082..2604293	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JMO11_RS13235	2604416..2604889	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T212100 WP_000482650.1 NZ_CP080553:c2600251-2600144 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T212100 NZ_CP106964:c4951022-4950738 [Klebsiella variicola]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGATGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT212100 NZ_CP080553:2600067-2600127 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin