Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2574719..2575236 Replicon chromosome
Accession NZ_CP080553
Organism Staphylococcus aureus strain HL18380

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JMO11_RS13075 Protein ID WP_000113262.1
Coordinates 2574719..2574985 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag JMO11_RS13080 Protein ID WP_000584502.1
Coordinates 2574985..2575236 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO11_RS13045 (2570145) 2570145..2570681 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
JMO11_RS13050 (2570914) 2570914..2571738 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JMO11_RS13055 (2571955) 2571955..2572137 - 183 WP_000230294.1 hypothetical protein -
JMO11_RS13060 (2572221) 2572221..2572688 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JMO11_RS13065 (2572874) 2572874..2574424 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JMO11_RS13070 (2574613) 2574613..2574684 - 72 Protein_2537 hypothetical protein -
JMO11_RS13075 (2574719) 2574719..2574985 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JMO11_RS13080 (2574985) 2574985..2575236 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMO11_RS13085 (2575401) 2575401..2575502 - 102 WP_001791744.1 hypothetical protein -
JMO11_RS13090 (2575509) 2575509..2576108 - 600 WP_000162813.1 DsbA family protein -
JMO11_RS13095 (2576127) 2576127..2576486 - 360 WP_000819847.1 DUF4467 domain-containing protein -
JMO11_RS13100 (2576741) 2576741..2577991 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
JMO11_RS13105 (2578088) 2578088..2578819 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JMO11_RS13110 (2578816) 2578816..2579535 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T212099 WP_000113262.1 NZ_CP080553:c2574985-2574719 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T212099 NZ_CP106964:c4876853-4876479 [Klebsiella variicola]
ATGCAAATACAATCCATGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCGAAATCTGGCAAAAATTACTGGA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAGCACATTG
ATGCGGGTATCTCACTGTGTGACGCGGTGAATTTTATCGTGGAAAAGTACGGCTTGGTGCGTACTGACCGTCACGGCTTC
AGTGTGACAGAGCAGTCTCCGTTCATCGGCAGCATCGATATGCTCCGCGCCCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT212099 WP_000584502.1 NZ_CP080553:c2575236-2574985 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT212099 NZ_CP106964:c4877262-4876903 [Klebsiella variicola]
ATGAAGAAAGCAACCCGTATAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
GGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACA
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAGCAGATGGAGCTTATGCTGGCCAGCAGCGAACTCACG
CCCCGCATTCAGCGCTGCATCACGCTCCACGCAAAAGGGCTGATATGTGAGGCTGATACGCTCGGCTCCTGTGGCTATTT
GTATATCGTAATTTATCCGACATCTGCAATAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References