Detailed information of TA system TA212098

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2310012..2310229
• Replicon: chromosome
• Accession: NZ_CP080553
• Organism: Staphylococcus aureus strain HL18380

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JMO11_RS11685
• Protein ID: WP_001802298.1
• Coordinates: 2310125..2310229 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2310012..2310067 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO11_RS11665	2306149..2306814	-	666	WP_001024094.1	SDR family oxidoreductase	-
JMO11_RS11670	2306966..2307286	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JMO11_RS11675	2307288..2308268	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
JMO11_RS11680	2308534..2309625	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2310012..2310067	+	56	-	-	Antitoxin
JMO11_RS11685	2310125..2310229	-	105	WP_001802298.1	hypothetical protein	Toxin
JMO11_RS11690	2310390..2310873	-	484	Protein_2270	recombinase family protein	-
JMO11_RS11695	2310916..2312052	-	1137	WP_000115564.1	SAP domain-containing protein	-
JMO11_RS11700	2312341..2312433	+	93	WP_001790138.1	hypothetical protein	-
JMO11_RS14980	2312722..2312906	+	185	Protein_2273	exotoxin	-
JMO11_RS11705	2313138..2313995	-	858	WP_000370924.1	HAD family hydrolase	-
JMO11_RS11710	2314063..2314845	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212098 WP_001802298.1 NZ_CP080553:c2310229-2310125 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212098 NZ_CP106964:4209782-4210000 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212098 NZ_CP080553:2310012-2310067 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin